コネクトミック＆トランスレーショナル認知症研究セクター (Sector for CAT Dr.)
私たちは、基礎研究者と臨床研究者が力を合わせ、ヒトにおけるタウ・ネットワークマッピングと、非ヒト霊長類における遺伝学的回路操作を組み合わせた新たなアプローチで、認知症の病態回路メカニズムの因果的解明、及び認知症に対する新たなニューロモジュレーション治療法の開発を目指しています。またそれと並行して、非ヒト霊長類における遺伝学的回路操作、機能イメージング、及び電気生理の融合により、認知・情動機能を支えるネットワーク作動のマルチスケールな因果的理解を目指した基礎研究も進めています。
セクター長
平林 敏行 主幹研究員 （医学博士）
専門: ヒト認知症患者群におけるタウ・ネットワークマッピング; 非ヒト霊長類における化学遺伝学的回路操作と機能イメージング、電気生理の融合による認知記憶・情動機能を支えるネットワーク作動のマルチスケール因果性解析; 多細胞同時記録による認知記憶の局所回路作動解析
趣味・特技： ねこ
メンバー
平林 敏行 主幹研究員
高畑 圭輔 主任研究員
遠藤 浩信 主任研究員
堀 祐樹 研究員
互 健二 研究員
百田 友紀 博士研究員
黒瀬 心 実習生
主要論文：
Miyakawa, N., Nagai, Y., Hori, Y., Mimura, K., Orihara, A., Oyama, K., Matsuo, T., Inoue, K., Suzuki, T., Hirabayashi, T., Suhara, T., Takada, M., Higuchi, M., Kawasaki, K., Minamimoto, T. Chemogenetic attenuation of cortical seizures in nonhuman primates. Nature Commun. (2023) 14, 971.
Hori, Y., Nagai, Y., Hori, Y., Oyama, K., Mimura, K., Hirabayashi, T., Inoue, K., Fujinaga, M., Zhang, M-R., Takada, M., Higuchi, M., Minamimoto, T. Multimodal Imaging for Validation and Optimization of Ion Channel-Based Chemogenetics in Nonhuman Primates. J. Neurosci. (2023) 43, 6619-6627.
Endo, H., Tagai, K., Ono, M., Ikoma, Y., Oyama, A., Matsuoka, K., Kokubo, N., Hirata, K., Sano, Y., Oya, M., Matsumoto, H., Kurose, S., Seki C, Shimizu H, Kakita A, Takahata, K., Shinoto, H., Shimada, H., Tokuda, T., Kawamura, K., Zhang, MR, Oishi, K., Mori, S., Takado, Y., Higuchi, M. A Machine Learning–Based Approach to Discrimination of Tauopathies Using [18F]PM-PBB3 PET Images. Mov Disord., 2022, 37, 2236-2246.
Momota, Y., Konishi, M., Takahata, K., Kishimoto, T., Tezuka, T., Bun, S., Tabuchi, H., Ito, D., Mimura, M. Case report: Non-Alzheimer's disease tauopathy with logopenic variant primary progressive aphasia diagnosed using amyloid and tau PET. Front Neurol. (2022) 13, 1049113.
*Hirabayashi, T., Nagai, Y., Hori, Y., Inoue, K., Aoki, I., Takada, M., Suhara, T., Higuchi, M., Minamimoto, T. Chemogenetic sensory fMRI reveals behaviorally relevant bidirectional changes in primate somatosensory network. Neuron (2021) 109, 3312-3322. (*: corresponding author)
Tagai, K., Ono, M., Kubota, M., Kitamura, S., Takahata, K., Seki, C., Takado, Y., Shinotoh, H., Sano, Y., Yamamoto, Y., Matsuoka, K., Takuwa, H., Shimojo, M., Takahashi, M., Kawamura, K., Kikuchi, T., Okada, M., Akiyama, H., Suzuki, H., Onaya, M., Takeda , T., Arai, K., Arai, N., Araki, N., Saito, Y., Trojanowski, JQ., Lee, VMY., Mishra, SK., Yamaguchi, Y., Kimura, Y., Ichise, M., Tomita, Y., Zhang, M-R., Suhara, T., Shigeta, M., Sahara, N., Higuchi, M., Shimada, H. High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies. Neuron (2021) 109, 42-58.
Oyama, K., Hori, Y., Nagai, Y., Miyakawa, N., Mimura, K., Hirabayashi, T., Inoue, K., Suhara, T., Takada, M., Higuchi, M., Minamimoto, T. Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making. Science Adv. (2021) 7, eabg4246.
Kurose, S., Kubota,M., Takahata, K., Yamamoto, Y., Fujiwara, H., Kimura, Y., Ito, H., Takeuchi, H., Mimura, M., Suhara, T., Higuchi, M. Relationship between regional gray matter volumes and dopamine D2 receptor and transporter in living human brains. (2021) Hum Brain Mapp. 42, 4048-4058.
Nagai, Y., Miyakawa, N., Takuwa, H., Hori, Y., Oyama, K., Ji, B., Takahashi, M., Huang, XP., Slocum, ST., DiBerto, JF., Xiong, Y., Urushihata, T., Hirabayashi, T., Fujimoto, A., Mimura, K., English, JG., Liu, J., Inoue, K., Kumata, K., Seki, C., Ono, M., Shimojo, M., Zhang, MR., Tomita, Y., Nakahara, J., Suhara, T., Takada, M., Higuchi, M., Jin, J., Roth, BL., Minamimoto, T. Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys. Nature Neurosci. (2020) 23, 1157-1167.
Takahata, K., Kimura, Y., Sahara, N., Koga, S., Shimada, H., Ichise, M., Saito, F., Moriguchi, S., Kitamura, S., Kubota, M., Umeda, S., Niwa, F., Mizushima, J., Yoko Morimoto, Y., Funayama, M., Tabuchi, H., Bieniek, KF., Kawamura, K., Zhang, M-R., Dickson, DW., Mimura, M., Kato, M., Suhara, T., Higuchi, M. PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury. Brain (2019) 142, 3265-3279.
Takeda, M., Hirabayashi, T., Adachi, Y., Miyashita, Y. Dynamic laminar rerouting of inter-areal mnemonic signal by cognitive operations in primate temporal cortex. Nature Commun. (2018) 9, 4629.
Tamura, K., Takeda, M., Setsuie, R., Tsubota, T., Hirabayashi, T., Miyamoto, K., Miyashita, Y. Conversion of object identity to object-general semantic value in the primate temporal cortex. Science. (2017) 357, 687-692.
Koyano, K.W., Takeda M., Matsui, T., Hirabayashi, T., Ohashi, Y., Miyashita, Y. Laminar module cascade from layer 5 to 6 implementing cue-to-target conversion for object memory retrieval in the primate temporal cortex. Neuron. (2016) 92, 518-529.
Nagai, Y., Kikuchi, E., Lerchner, W., Inoue, K., Ji, B., Eldridge, MAG. Kaneko, H., Kimura, Y., Oh-Nishi, A., Hori, Y., Kato, Y., Hirabayashi, T., Fujimoto, A., Kumata, K., Ming-Rong Zhang, M-R., Aoki, I., Suhara, T., Higuchi M., Takada, M., Richmond, BJ., Minamimoto, T. PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation. Nature Commun. (2016) 7, 13605.
*Hirabayashi, T., Tamura, K., Takeuchi, D., Takeda, M., Koyano, K.W., Miyashita, Y. Distinct neuronal interactions in anterior inferotemporal areas of macaque monkeys during retrieval of object association memory. J. Neurosci. (2014) 34, 9377-9388. (*: corresponding author)
Hirabayashi, T., Miyashita, Y. Computational principles of microcircuits for visual object processing in the macaque temporal cortex. Trends Neurosci. (2014) 37, 178-187.
Hirabayashi, T., Takeuchi, D., Tamura, K., Miyashita, Y. Microcircuits for hierarchical elaboration of object coding across primate temporal areas. Science. (2013) 341, 191-195.
Hirabayashi, T., Takeuchi, D., Tamura, K., Miyashita, Y. Functional micro-circuit recruited during retrieval of object association memory in monkey perirhinal cortex. Neuron. (2013) 77, 192-203.
#Miyamoto, K., #Hirabayashi, T., Miyashita, Y. To bet, or not to bet: that is the question of SEF spikes. Neuron. (2012) 75, 358-360. (#: These authors equally contributed.)
Takeuchi, D., Hirabayashi, T., Tamura, K., Miyashita, Y. Reversal of interlaminar signal between sensory and memory processing in monkey temporal cortex. Science. (2011) 331, 1443-1447.
Hirabayashi, T., Takeuchi, D., Tamura, K., Miyashita, Y. Triphasic dynamics of stimulus-dependent information flow between single neurons in macaque inferior temporal cortex. J. Neurosci. (2010) 30, 10407-10421.
Hirabayashi, T., Miyashita, Y. Dynamically modulated spike correlation in monkey inferior temporal cortex depending on the feature configuration within a whole object. J. Neurosci. (2005) 25, 10299-10307.
