発表論文

2026

Radiosynthesis and quality control testing of two 18F-labeled radiopharmaceuticals for α-synuclein imaging in clinical investigations

Hashimoto Hiroki, Takayuki Ohkubo, Kawamura Kazunori, Tomoya Fujishiro, Arashi Daisuke, Sato Tatsuto, Seki Takeru, Muto Masatoshi, Tsukagoe Kaito, Ogawa Masanao, Yusuke Kurihara, Nengaki Nobuki, Mori Wakana, Fujinaga Masayuki, Higuchi Makoto, Zhang Ming-Rong

EJNMMI radiopharmacy and chemistry (2026-09)
Independent and Interactive Associations of General Expectation and Optimistic Prediction with Hopelessness

Isato Ayako, Yamada Makiko

Acta Psychologica (2026-06)
Property-damage-only crashes as predictors of injury crashes in older drivers

山本保天

Transportation Research Part F: Traffic Psychology and Behaviour (2026-06)

DOI
Exploratory case series of conversion to carbon ion radiotherapy after systemic therapy in advanced hepatocellular carcinoma.

Haruka Anzai, Chihiro Miwa, Sadahisa Ogasawara, Makoto Fujiya, Hiroki Kurosaki, Takahiro Tsuchiya, Ryohei Yoshino, Keiichi Katayama, Midori Sawada, Teppei Akatsuka, Ryo Izai, Takuya Yonemoto, Sae Yumita, Keisuke Koroki, Masanori Inoue, Masato Nakamura, Naoya Kanogawa, Shingo Nakamoto, Hirokazu Makishima, Makoto Shinoto, Masaru Wakatsuki, Shigeru Yamada, Hitoshi Ishikawa, Jun Kato

International cancer conference journal (2026-05)

DOI
Sub-0.5 mm Resolution PET Scanner with 3-Layer DOI Detectors for Rodent Neuroimaging

Hangyu Kang, Tashima Hideaki, Wakizaka Hidekatsu, Higuchi Makoto, Yamaya Taiga

IEEE Transactions on Medical Imaging, 45(4): 1423–1431 (2026-04)

DOI
Sub–0.5-mm Resolution PET Versus Autoradiography: Comparison of mGluR1 Concentrations in Mouse Brain

Hangyu Kang, Tashima Hideaki, Wakizaka Hidekatsu, Minamihisamatsu Takeharu, Yamasaki Tomoteru, Fujinaga Masayuki, Zhang Ming-Rong, Higuchi Makoto, Yamaya Taiga

Journal of Nuclear Medicine (2026-04)

DOI
Altered astrocyte–neuron crosstalk in progressive supranuclear palsy: Integrated evidence from proteomics and magnetic resonance spectroscopy

Ono Maiko, Yuta Kumagai, Hirata Kosei, Yuki Maeda, Yurika Abe, Endo Hironobu, Hiroshi Shimizu, Akiyoshi Kakita, Yasuo Uchida, Takado Yuhei

Acta neuropathologica, 151(1): 45 (2026-04)

DOI
Intrinsic recreation of moderately uncertain events in macaques

Sakumi Iki, Haruhiko Iwaoki, Yuko Hattori, Ikuma Adachi

Intrinsic recreation of moderately uncertain events in macaques (2026-04)

DOI
ネガティブ・ケイパビリティの認知科学的再構成：量子ゼノン効果の構造的メタファーに基づく理論的展望

山田真希子

認知科学, 33(1): 1–10 (2026-03)

DOI
Comparison of three plasma p-tau217 assays to detect PET-confirmed Alzheimer's pathologies.

Sayo Matsuura, Kenji Tagai, Harutsugu Tatebe, Hideki Matsumoto, Ryoji Goto, Asaka Oyama, Yuki Momota, Masanori Ichihashi, Yuko Kataoka, Kiwamu Matsuoka, Naomi Kokubo, Tetsuji Kamada, Kenta Osawa, Yoshikazu Chishiki, Sho Moriguchi, Yuki Komatsu, Chie Seki, Keisuke Takahata, Hironobu Endo, Takashi Kudo, Makoto Higuchi, Takahiko Tokuda

Alzheimer's & dementia (Amsterdam, Netherlands), 18(1) (2026-03)
Design optimization using GATE Monte Carlo simulations for a sub-0.5 mm resolution PET scanner with 3-layer DOI detectors

Hangyu Kang, Tashima Hideaki, Higuchi Makoto, Yamaya Taiga

Physics in Medicine and Biology, 71(3) (2026-02)

DOI
Temporal-orbitofrontal pathway regulates choices across physical reward and visual novelty.

Takaya Ogasawara, Kevin Xu, Abraham Z Snyder, Joel S Perlmutter, Zhude Tu, Takafumi Minamimoto, Ken-Ichi Inoue, Masahiko Takada, Ilya E Monosov

Neuron (2026-02)

DOI
Everything everywhere all at once: Exploring the richness of visual experience beyond words.

Liang Qianchen, Aizawa Yasunori, Yamada Makiko, Tsuchiya N

Peer J (2026-02)

DOI
Facial Emotional Expression in Reaction to Internet Gaming Videos Among Young Adults: A Preliminary and Exploratory Study

Nanase Kobayashi, Daisuke Jitoku, Masato Nishihara, Yuka Fujimoto, Chenyu Qian, Shoko Okuzumi, Shisei Tei, Takehiro Tamura, Hidehiko Takahashi, Takefumi Ueno, Yamada Makiko, Junya Fujino

Neuropsychopharmacology Reports (2026-02)

DOI
Longitudinal imaging evaluation of the inflammatory role of purinergic AA receptors during subacute and chronic ischemic stroke.

Maider Garbizu, Naroa Mocha-Muñoz, Esther Rubio-López, Laura Palacios, Laura Aguado, María Ardaya, Ana Joya, Unai Alduntzin, Sandra Plaza-García, Daniel Padro, Vanessa Gómez-Vallejo, Unai Cossío, Makoto Higuchi, Pedro Ramos-Cabrer, José Luis Zugaza, Jordi Llop, Abraham Martín

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 46(2): 456–472 (2026-02)

DOI
Correction and utilization of the washout effect in range-verificationPET for particle therapy

Toramatsu Chie, Yamaya Taiga, Kanno Iwao

Radiological Physics and Technology (2026-01)

DOI
A novel small molecule that enhances lysyl hydroxylase 2 activity and matrix mineralization

Saori Tomiku, Atsushi Kasamatsu, Reo Fukushima, Tomoaki Saito, Ryunosuke Nozaki, Akiko Suganami, Yutaka Tamura, Mitsuo Yamauchi, Katsuhiro Uzawa

Biochem Biophys Rep, 42: 102053 (2026-01)

DOI
DA-Raf synergistically binds to the plasma membrane and Ras to suppress ERK signaling

Kazunori Takano, Kazuya Tsujita, Akiko Suganami, Takuhiko Nakamura, Emiri Kanno, Yutaka Tamura, Toshiki Itoh, Takeshi Endo

Life Sci Alliance, 8(12): e202503300 (2026-01)

DOI
Encoding of odor information and reward anticipation in anterior cortical amygdaloid nucleus

Kazuki Shiotani, Yuta Tanisumi, Junya Hirokawa, Yoshio Sakurai, Hiroyuki Manabe

iScience (2026-01)

DOI
In vivo quantitative assessments with [11C]T-278, a PET imaging agent for diacylglycerol kinase gamma, in nonhuman primate brain

Yasushi Hattori, Yamasaki Tomoteru, Nagai Yuji, Okauchi Takashi, Fujinaga Masayuki, Mori Wakana, Minamimoto Takafumi, Higuchi Makoto, Tatsuki Koike, Zhang Ming-Rong

NeuroImage (2026-01)

DOI
Effects of Extended-Release Methylphenidate on Dopamine and Norepinephrine Transporters in Adults With Attention-Deficit/Hyperactivity Disorder: A Longitudinal Dual-Tracer PET Study.

Masaki Oya, Kiwamu Matsuoka, Manabu Kubota, Soichiro Kitamura, Yuko Kataoka, Naomi Kokubo, Keisuke Takahata, Chie Seki, Hironobu Endo, Kenji Tagai, Yuhei Takado, Kosei Hirata, Masanori Ichihashi, Shin Kurose, Nobumasa Kato, Genichi Sugihara, Masaaki Shimizu, Shunsuke Takagi, Wakako Ito, Motoaki Nakamura, Makoto Higuchi, Hidehiko Takahashi

Psychiatry and clinical neurosciences, 80(1): 48–54 (2026-01)

DOI
Florzolotau (18F) retention is linked to neuropsychological performance in tauopathy.

Atsushi Shimizu, Yu Iwabuchi, Shogyoku Bun, Memi Watanabe, Masahito Kubota, Sho Shimohama, Toshiki Tezuka, Keisuke Takahata, Hajime Tabuchi, Morinobu Seki, Yuki Momota, Yasuharu Yamamoto, Ryo Shikimoto, Yu Mimura, Shin Kurose, Ryosuke Sakurai, Toshiki Takayama, Yuka Hoshino, Takayuki Hoshino, Natsumi Suzuki, Ayaka Morimoto, Azusa Osumi, Masaru Mimura, Masahiro Jinzaki, Daisuke Ito

Alzheimer's & dementia : the journal of the Alzheimer's Association, 22(4): e71319 (2026-01)

2025

Noninvasive Imaging Reveals Cardiac Sympathetic Reinnervation in Pathological Hearts and Suppressed Norepinephrine Transporter Function in Healthy Hearts after Carbon Ion Irradiation in Rabbits

網野真理, 下川卓志, 脇坂秀克, 永井裕司, 辻厚至, 張明栄, 齋藤俊輝, Wataru Nakabayashi, Noboru Kawabe, Sachie Tanaka, 株木重人, Etsuo Kunieda, 吉岡公一郎

Heart Rhythm, 22(12): 3277–3288 (2025-12)

DOI
Association between decreased taurine levels in the anterior cingulate cortex and restricted and repetitive behaviors in autism spectrum disorder: a cross-sectional study

Akihiro Minami, 松岡究, Masato Takahashi, Kazuya Ueda, Hiroki Ohnishi, Yuka Fujimoto, Hiroaki Yoshikawa, Rio Ishida, 高堂裕平, Jamie Near, Yuya Yamatani, Toshiteru Miyasaka, Yumi Tai, Tomoko Ochi, Toshihiro Tanaka, Takashi Okada, Nakao Iwata, Manabu Makinodan

Frontiers in Psychiatry, 16: 1700059 (2025-12)

DOI
Non-invasive assessment of activated renal macrophages by imaging of colony-stimulating factor 1 receptor in mouse model with ischemic acute kidney injury

Sijun Chen, Xinran Zhao, Yanshan Li, Nailian Zhang, Xiyan Rui, Xuejing Guan, Fangfei Hu, Seki Chie, Xie Lin, Zhang Ming-Rong, Mei Tian, Bin Ji, Rong Zhou

Journal of Inflammation (2025-11)

DOI
Plasma Neurofilament Light Chain and Phosphorylated Tau Are Elevated in Myotonic Dystrophy Type 1

Masanori P Takahashi, Harutsugu Tatebe, Hiroto Takada, Takahiro Nakayama, Michio Kobayashi, Kosuke Yoshida, Satoshi Kuru, Natsuki Kira, Tomoya Kubota, Yasuaki Mizutani, Hirohisa Watanabe, Takado Yuhei, Tokuda Takahiko

Plasma Neurofilament Light Chain and Phosphorylated Tau Are Elevated in Myotonic Dystrophy Type 1, 14(22): 8197 (2025-11)

DOI
Lifting the veil: probing altered visual perception in derealization.

Kusztor A, Mulay N, Yamada Makiko, Hohwy J, Tsuchiya N

Neuroscience of Consciousness (2025-11)

DOI
Low-Cost Polyphenol-Polypyrrole Molecularly Imprinted Sensor for Point-of-Care Alzheimer's Detection.

Ajith Mohan Arjun, Sudhaunsh Deshpande, Guoyi Liu, Daimei Miura, Krzysztof Pawlak, Tokuda Takahiko, Makoto Higuchi, Miyu Matsumoto, Tomoko Umemura, Kaori Tsukakoshi, Sanjiv Sharma

ACS sensors, 10(11): 8435–8446 (2025-11)

DOI
Quantum-like representation of neuronal networks’ activity: modelling “mental entanglement”

Andrei Khrennikov, Yamada Makiko

Frontiers in Human Neuroscience (2025-10)

DOI
Longitudinal assessment of DREADD expression and efficacy in the monkey brain.

Yuji Nagai, Yukiko Hori, Ken-Ichi Inoue, Toshiyuki Hirabayashi, Koki Mimura, Kei Oyama, Naohisa Miyakawa, Yuki Hori, Haruhiko Iwaoki, Katsushi Kumata, Ming-Rong Zhang, Masahiko Takada, Makoto Higuchi, Takafumi Minamimoto

eLife, 14 (2025-10)

DOI
Discovery of Pyrazole-Based Positron Emission Tomography Agent that Maps Histone Deacetylase 6 (HDAC6) in the Nonhuman Primate Brain

Yamasaki Tomoteru, Norio Ohyabu, Wakabayashi Takeshi, Ignacio Ibáñez, Kouichi Iwanaga, Satoshi Yamamoto, Masahiko Hattori, Taku Sugita, Michiko Terada, Tomohiro Onishi, Sho Sato, Yohei Kosugi, Akihiro Takano, Paul McQuade, Takamitsu Maru, Naomi Inui, Fujinaga Masayuki, Mori Wakana, Nagai Yuji, Seki Chie, Uchida Shoko, Minamimoto Takafumi, Higuchi Makoto, Makoto Fushimi, Zhang Ming-Rong

Journal of Medicinal Chemistry (2025-10)

DOI
Prefronto-thalamic hypoconnectivity in schizophrenia: Monkey to human translation of critical pathways for symptom-related functions

Yahata Noriaki, Hirabayashi Toshiyuki, Minamimoto Takafumi

PCN Reports, 4(4): e70206 (2025-10)

DOI
Neuronal deterioration associated with hyperexcitability under mild chronic cerebral hypoperfusion.

Takuya Urushihata, Manami Takahashi, Masafumi Shimojo, Yuhei Takado, Nobuhiro Nitta, Yosuke Tajima, Kazuto Masamoto, Iwao Kanno, Yutaka Tomita, Naruhiko Sahara, Masaya Takahashi, Takayuki Obata, Hiroshi Ito, Tetsuro Yamashita, Tetsuya Suhara, Makoto Higuchi, Hiroyuki Takuwa

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 45(10): 1932–1946 (2025-10)

DOI
A longitudinal PET study on changes in brain norepinephrine transporter availability following duloxetine treatment in major depressive disorder.

Sho Moriguchi, Keisuke Takahata, Harumasa Takano, Hironobu Endo, Kenji Tagai, Soichiro Kitamura, Hiroyuki Uchida, Masaru Mimura, Manabu Kubota, Ming-Rong Zhang, Makoto Higuchi

The international journal of neuropsychopharmacology, 28(10) (2025-10)
Quantification of monoamine oxidase B expression with C-SL25.1188 for imaging reactive astrocytes in patients with Alzheimer's disease.

Kiwamu Matsuoka, Yuhei Takado, Yasuyuki Kimura, Akihiko Kitamura, Hitomi Kitamura, Mayuka Kanda, Michihiro Takada, Maiko Ono, Harutsugu Tatebe, Hironobu Endo, Shin Kurose, Keisuke Takahata, Yoko Ikoma, Masanori Ichihashi, Masaki Oya, Kosei Hirata, Hideki Matsumoto, Asumi Orihara, Naomi Kokubo, Yuko Kataoka, Hong Zhang, Kenji Tagai, Chie Seki, Hitoshi Shinotoh, Tatsuya Kikuchi, Masanori Ichise, Hiroshi Shimizu, Akiyoshi Kakita, Kazunori Kawamura, Ming-Rong Zhang, Hitoshi Shimada, Kenji Nagao, Takahiko Tokuda, Makoto Higuchi

European journal of nuclear medicine and molecular imaging (2025-09)

DOI
不定性に宿る希望の認知科学

山田真希子, 布山美慕（立命館大学）

認知科学, 32(3): 324–328 (2025-09)
不定性を基盤とする他者や世界への働きかけ

布山美慕（立命館大学）, 山田真希子

認知科学, 32(3): 329–338 (2025-09)
〈前向き〉概念とその哲学的含意：逆境に駆動された肯定性のダイナミクス

田口茂（北海道大学）, 宮崎勝正（北海道大学）, 藏田伸雄（北海道大学）, 廣瀬健司（北海道大学）, 山田真希子

認知科学, 32(3): 339–351 (2025-09)
Neural Correlates of Resistance to Gaming Desire Induced by Social Media Content.

Yuka Fujimoto, Junya Fujino, Daisuke Matsuyoshi, Daisuke Jitoku, Nanase Kobayashi, Chenyu Qian, Shoko Okuzumi, Shisei Tei, Takehiro Tamura, Takefumi Ueno, Makiko Yamada, Hidehiko Takahashi

Addiction biology, 30(9): e70085 (2025-09)
Imaging of Proteinopathies in the Brains of Parkinsonian Disorders.

Makoto Higuchi

Cells, 14(18) (2025-09)

DOI
A Case of Late-Onset Semantic Dementia With Right-Predominant Temporal Lobe Atrophy due to Primary Tauopathy.

Yuta Sudo, Masashi Tamura, Kenjiro Nakayama, Kiyotaka Nemoto, Osamu Yokota, Kenji Tagai, Hironobu Endo, Takahiko Tokuda, Makoto Higuchi, Kentaro Hatano, Tetsuaki Arai

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 25(5): e70094 (2025-09)
Advances in PET imaging of protein aggregates associated with neurodegenerative disease.

Makoto Higuchi, Kenji Tagai, Keisuke Takahata, Hironobu Endo

Nature reviews. Neurology, 21(9): 506–522 (2025-09)

DOI
Development of a submillimeter resolution PET scanner with compact geometry for hybrid multi-photon/PET imaging

Hangyu Kang, Takuwa Hiroyuki, Tashima Hideaki, Wakizaka Hidekatsu, Higuchi Makoto, Yamaya Taiga

Physics in Medicine and Biology, 70(17) (2025-08)

DOI
Concurrent Alzheimer's disease pathologies in Lewy body diseases affect cognition and glucose metabolism in the posterior cingulate gyrus: A multimodal PET study

Kosei Nakamura, Tagai Kenji, Shinoto Hitoshi, Hirano Shigeki, Kitamura Soichiro, Endo Hironobu, Takahata Keisuke, Takado Yuhei, Zhang Ming-Rong, Kawamura Kazunori, Osamu Onodera, Higuchi Makoto, Shimada Hitoshi

Journal of Alzheimer's Disease (2025-07)

DOI
Neuropathological correlations of F-florzolotau PET in a case with Pick’s disease.

Hisaomi Suzuki, Manabu Kubota, Shin Kurose, Kenji Tagai, Hironobu Endo, Mitsumoto Onaya, Yasuharu Yamamoto, Naruhiko Sahara, Masahiro Ohgidani, Chie Haga, Hiroya Hara, Haruhiko Akiyama, Keisuke Takahata, Makoto Higuchi

EJNMMI research, 15(1): 96 (2025-07)

DOI
A Cautionary Note on the Indication for Deep Brain Stimulation in Parkinsonism Patients With SLC9A6 Gene Mutations.

Shohei Okusa, Toshiki Tezuka, Kenzo Kosugi, Yasuharu Yamamoto, Keisuke Takahata, Makoto Higuchi, Takenori Akiyama, Masahito Kobayashi, Masahiro Toda, Daisuke Ito, Jin Nakahara, Morinobu Seki

Journal of movement disorders, 18(3): 268–270 (2025-07)

DOI
Rod‐shaped microglia represent a morphologically distinct subpopulation of disease‐associated microglia

Yukio Matsuba, Kenichi Nagata, Yosuke Kadota, Sahara Naruhiko, Takaomi C. Saido, Shoko Hashimoto

Journal of Neuroin_x001F_ammation (2025-07)

DOI
Clinical and Pathological Features of FTDP-17 with MAPT p.K298_H299insQ Mutation

Hiroyuki Morino, Takashi Kurashige, Yukiko Matsuda, Ono Maiko, Sahara Naruhiko, tomohiro Miyasaka, Yoshiyuki Soeda, Shimada Hitoshi, Yu Yamazaki, Tetsuya Takahashi, Yuishin Izumi, Hidefumi Ito, Hirofumi Maruyama, Higuchi Makoto, Koji Arihiro, Suhara Tetsuya, Akihiko Takashima

Mov Disord Clin Pract, 11(6): 720–727 (2025-06)
Development of a Novel Positron Emission Tomography Probe Deuterated [18F]FE-TMP ([18F]FE-TMP-d4), an Antagonist of Escherichia coli Dihydrofolate Reductase, for Reporter Gene Imaging of the Brain

Fujinaga Masayuki, Takayuki Ohkubo, Shimojo Masafumi, Nagai Yuji, Ono Maiko, Matsushita Yumi, Mimura Koki, Mori Wakana, Yiding Zhang, Yusuke Kurihara, Ogawa Masanao, Nengaki Nobuki, Minamimoto Takafumi, Higuchi Makoto, Yamasaki Tomoteru, Zhang Ming-Rong

Journal of Medicinal Chemistry (2025-06)

DOI
Diverse tau pathologies in late-life mood disorders revealed by PET and autopsy assays.

Shin Kurose, Sho Moriguchi, Manabu Kubota, Kenji Tagai, Yuki Momota, Masanori Ichihashi, Yasunori Sano, Hironobu Endo, Kosei Hirata, Yuko Kataoka, Ryoji Goto, Yuki Mashima, Yasuharu Yamamoto, Hisaomi Suzuki, Shinichiro Nakajima, Masashi Mizutani, Terunori Sano, Kazunori Kawamura, Ming-Rong Zhang, Harutsugu Tatebe, Takahiko Tokuda, Mitsumoto Onaya, Masaru Mimura, Naruhiko Sahara, Hidehiko Takahashi, Hiroyuki Uchida, Masaki Takao, Jeffrey H Meyer, Makoto Higuchi, Keisuke Takahata

Alzheimer's & dementia : the journal of the Alzheimer's Association, 21(6): e70195 (2025-06)
iPSC screening identifies CACNA2D2 as a potential therapeutic target for FTLD-Tau.

Keiko Imamura, Ayako Nagahashi, Aya Okusa, Tomoki Sakasai, Kayoko Tsukita, Yumiko Kutoku, Yutaka Ohsawa, Yoshihide Sunada, Naruhiko Sahara, Nicholas M Kanaan, Makoto Higuchi, Kohji Mori, Manabu Ikeda, Haruhisa Inoue

European journal of cell biology, 104(2): 151484 (2025-06)

DOI
Plasma biomarkers for early detection of alzheimer’s disease: a cross-sectional study in a Japanese cohort

Masahito Kubota, Shogyoku Bun, Takahata Keisuke, Kurose Shin, Momota Yuki, Yu Iwabuchi, Toshiki Tezuka, Hajime Tabuchi, Morinobu Seki, Yamamoto Yasuharu, Ryo Shikimoto, Yu Mimura, Takayuki Hoshino, Sho Shimohama, Natsumi Suzuki, Ayaka Morimoto, Azusa Oosumi, Yuka Hoshino, Kenji Tai, Hirofumi Aoyagi, Yoshiaki Sato, Junro Kuromitsu, Jin Nakahara, Masaru Mimura, Daisuke Ito

Alzheimer's Research & Therapy (2025-06)

DOI
Functional Heterogeneity within the Primate Ventral Striatum for Motivational Regulation

Iwaoki Haruhiko, Hori Yukiko, Hori Yuki, Mimura Koki, Oyama Kei, Nagai Yuji, Hirabayashi Toshiyuki, Inoue Ken-ichi, Takada Masahiko, Higuchi Makoto, Minamimoto Takafumi

The Journal of Neuroscience, 45(21) (2025-05)

DOI
Evaluation of in vivo and in vitro binding property of a novel candidate PET tracer for CSF1R imaging and comparison with two currently-used CSF1R-PET tracers

Rui Xiyan, Yuzhou Ding, Nailian Zhang, Xinran Zhao, Seki Chie, Yamasaki Tomoteru, Fujinaga Masayuki, Zhang Ming-Rong, Jun Qian, Bin Ji, Rong Zhou

EJNMMI radiopharmacy and chemistry, 10(23) (2025-05)

DOI
Effects of gaming content from social media on individuals with internet gaming disorder: an fMRI study.

Yuka Fujimoto, Junya Fujino, Daisuke Matsuyoshi, Daisuke Jitoku, Nanase Kobayashi, Chenyu Qian, Shoko Okuzumi, Shisei Tei, Takehiro Tamura, Takefumi Ueno, Makiko Yamada, Hidehiko Takahashi

Cerebral cortex (New York, N.Y. : 1991), 35(4): bhaf096 (2025-04)
Potent activity of prostaglandin J2 on prostanoid DP receptors

Kanaho Senoo, Keijo Fukushima, Hitomi Yamamoto, Ayaka Hamaguchi, Akiko Suganami, Harumi Takano, Mayu Yamashita, John W Regan, Yutaka Tamura, Hiromichi Fujino

J Biol Chem, 301(6): 108523 (2025-04)

DOI
Quantum-like Qualia hypothesis: from Quantum Cognition to Quantum Perception

Naotsugu Tsuchiya, Peter Bruza, Yamada Makiko, Hayato Saigo, Emmanuel M Pothos

Front Psychol, 15(1) (2025-04)
Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community

Takahiro Morito, Mohan Qi, Naoko Kamano, Hiroki Sasaguri, Sumi Bez, Martha Foiani, Karen Duff, Seico Benner, Toshihiro Endo, Hiroshi Hama, Hiroshi Kurokawa, Atushi Miyawak, Mizuma Hiroshi, Sahara Naruhiko, Shimojo Masafumi, Higuchi Makoto, Takaomi C Saido, Naoto Watamura

Cell Rep Methods, 5: 101024 (2025-04)

DOI
A neuroimaging dataset during sequential color qualia similarity judgments with and without reports

Hirao Takahiro, Miyamae Mitsuhiro, Matsuyoshi Daisuke, Inoue Ryuto, Takado Yuhei, Obata Takayuki, Higuchi Makoto, Naotsugu Tsuchiya, Yamada Makiko

Scientific Data, 12(389): 1–12 (2025-03)

DOI
Superiority Illusion in Older Adults: Volume and Functional Connectivity of the Precuneus

Shidei Yuki, Matsuyoshi Daisuke, Isato Ayako, Genichi Sugihara, Hidehiko Takahashi, Yamada Makiko

Psychiatry and Clinical Neurosciences Reports, 4(1): e70046 (2025-03)

DOI
Formation of brain-wide neural geometry during visual item recognition in monkeys

He Chen, Jun Kunimatsu, Tomomichi Oya, Yuri Imaizumi, Yukiko Hori, Masayuki Matsumoto, Yasuhiro Tsubo, Okihide Hikosaka, Takafumi Minamimoto, Yuji Naya, Hiroshi Yamada

iScience, 28(3): 111936 (2025-03)

DOI
Human biodistribution and radiation dosimetry of two novel α-synuclein PET tracers, F-SPAL-T-06 and F-C05-05.

Ryoji Goto, Kiwamu Matsuoka, Yasuyuki Kimura, Yuko Kataoka, Masaki Oya, Kosei Hirata, Kenji Tagai, Keisuke Takahata, Chie Seki, Kazunori Kawamura, Ming-Rong Zhang, Makoto Higuchi, Hironobu Endo

Scientific reports, 15(1): 8640 (2025-03)

DOI
Awake brain MRSI reveals anesthetic sensitivity and regional aging effects on [13C]bicarbonate metabolism in mice

Ono Maiko, Kono Rena, Hirata Kosei, Saito Keita, Nakao Motonao, Takakusagi Yoichi, Rikita Araki, Sumiyoshi Akira, Takado Yuhei

Frontiers in Neuroimaging, 4 (2025-02)

DOI
The role of memory in affirming-the-consequent fallacy

Yoko Higuchi, Ethan Oblak, Yamada Makiko, Hiroko Nakamura, Kazuhisa Shibata

iScience, 28(2): 111889 (2025-02)

DOI
Remote Cortical Network for Frontal Cognitive Symptoms derived from Tau Accumulation in Progressive Supranuclear Palsy

Hori Yuki, Endo Hironobu, Tagai Kenji, Kataoka Yuko, Goto Ryoji, Kurose Shin, Momota Yuki, Kokubo Naomi, Seki Chie, Moriguchi Sho, Shimada Hitoshi, Shinoto Hitoshi, Tokuda Takahiko, Takahata Keisuke, Minamimoto Takafumi, Higuchi Makoto, Hirabayashi Toshiyuki

bioRxiv (2025-02)

DOI
SLC9A6-Linked Parkinson Syndrome in Female Heterozygotes Is Associated With PET-Detectable Tau Pathology

Yasuharu Yamamoto, Takahata Keisuke, Morinobu Seki, Shohei Okusa, Tatebe Harutsugu, Ryo Ueda, Endo Hironobu, Tagai Kenji, Moriguchi Sho, Kurose Shin, Ichihashi Masanori, Matsuura Sayo, Kawamura Kazunori, Zhang Ming-Rong, Yuji Ueno, Yoshihisa Takiyama, Tokuda Takahiko, Higuchi Makoto, Daisuke Ito

Neurology: Gentics, 13(11): e200235 (2025-01)

DOI
Alterations of striatal phosphodiesterase 10 A and their association with recurrence rate in bipolar I disorder

佐野康徳, 山本保天, 久保田学, 森口翔, 松岡究, 黒瀬心, 互健二, 遠藤浩信, Bun Yamagata, 鈴木寿臣, Ryosuke Tarumi, Kie Nomot, 高堂裕平, 河村和紀, 張明栄, Hajime Tabuchi, Masaru Mimura, Hiroyuki Uchida, 樋口真人, 高畑圭輔

Translational psychiatry, 14(1): 403 (2025-01)

DOI

2024

TRPC6 is a mechanosensitive channel essential for ultrasound neuromodulation in the mammalian brain

Matsushita Yumi, Yoshida Kaed, Yoshiya Miyuki, Takahiro Shimizu, Tsukamoto Satoshi, Kudo Nobuki, Takeuchi Yuichi, Higuchi Makoto, Shimojo Masafumi

PNAS, 10(121): 50 (2024-12)

DOI
Neural Correlates of Category Learning in Monkey Inferior Temporal Cortex

Jonah E. Pearl, Matsumoto Narihisa, Hayashi Kazuko, Matsuda Keiji, Miura Kenichiro, Nagai Yuji, Miyakawa Naohisa, Minamimoto Takafumi, Richard C. Saunders, Sugase-Miyamoto Yasuko, Barry J. Richmond, Mark A. G. Eldridge

Journal of Neuroscience, 44(49): 1–12 (2024-12)

DOI
Cross-Species Convergence of Functional Connectivity Changes in Thalamic Pain Across Human Patients and Model Macaques

Dong Dong, Koichi Hosomi, Takeshi Shimizu, Ken-ichi Okada, Yoshinori Kadono, Nobuhiko Mori, 堀祐樹, 八幡憲明, 平林敏行, Haruhiko Kishima, Youichi Saitoh

The Journal of pain, 25(12) (2024-12)

DOI
A novel tauopathy model mimicking molecular and spatial aspects of human tau pathology.

Rin Yanai, Tomoki T Mitani, Etsuo A Susaki, Takeharu Minamihisamatsu, Masafumi Shimojo, Yuri Saito, Hiroshi Mizuma, Nobuhiro Nitta, Daita Kaneda, Yoshio Hashizume, Gen Matsumoto, Kentaro Tanemura, Ming-Rong Zhang, Makoto Higuchi, Hiroki R Ueda, Naruhiko Sahara

Brain communications (2024-12)

DOI
Development of a novel radioiodinated compound for amyloid and tau deposition imaging in Alzheimer's disease and tauopathy mouse models

Xiyan Rui, Xinran Zhao, Nailian Zhang, Yuzhou Ding, Seki Chie, Ono Maiko, Higuchi Makoto, Zhang Ming-Rong, Yong Chu, Ruonan Wei, Miaomiao Xu, Chao Cheng, Changjing Zuo, Yasuyuki Kimura, Ruiqing Ni, Mototora Kai, Mei Tian, Chunyan Yuan, Bin Ji

Neuroimage (2024-12)

DOI
ネガティブ・ケイパビリティ尺度の開発と妥当化

玉木賢太郎, 伊里綾子, 山田真希子

Jxiv (2024-12)

DOI
Distinct tau pathologies in the nucleus basalis of Meynert between early-onset and late-onset Alzheimer's disease patients revealed by positron emission tomography

Suzuki Hisaomi, Tagai Kenji, Ono Maiko, Hiroshi Shimizu, Endo Hironobu, Matsumoto Hideki, Kubota Manabu, Kataoka Yuko, Moriguchi Sho, Kurose Shin, Ichihashi Masanori, Shinoto Hitoshi, Matsuoka Kiwamu, Kokubo Naomi, Tatebe Harutsugu, Matsuura Sayo, Yasuharu Yamamoto, Momota Yuki, Kawamura Kazunori, Zhang Ming-Rong, Takado Yuhei, Shimada Hitoshi, Tokuda Takahiko, Mitsumoto Onaya, Masaru Mimura, Akiyoshi Kakita, Sahara Naruhiko, Hiroyuki Uchida, Higuchi Makoto, Takahata Keisuke

Journal of Alzheimer’s Disease (2024-11)

DOI
Can the clinical sign "head-turning sign" and simple questions in "Neucop-Q" predict amyloid β pathology?

Takahata Keisuke, Momota Yuki, Yasuharu Yamamoto, Kurose Shin

Alzheimer's research & therapy (2024-11)

DOI
Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior

Takahito Miyake, Tanaka Kaho, Yutsuki inoue, Nagai Yuji, Nishimura Reo, Seta Takehito, Nakagawa Shumpei, Inoue Ken-ichi, Hasegawa Emi, Minamimoto Takafumi, Doi Masao

Cell Reports Methods (2024-10)

DOI
Unsupervised decomposition of natural monkey behavior into a sequence of motion motifs.

Koki Mimura, Jumpei Matsumoto, Daichi Mochihashi, Tomoaki Nakamura, Hisao Nishijo, Makoto Higuchi, Toshiyuki Hirabayashi, Takafumi Minamimoto

Communications biology, 7(1): 1080 (2024-09)

DOI
信念更新における量子ゼノン効果

Tamaki Kentaro, Yamada Makiko

日本生物学的精神医学会誌, 35(3): 141–144 (2024-09)

DOI
A Longitudinal Study of the Impact of COVID-19 on Optimism Prediction.

Isato Ayako, Aizawa Yasunori, Miyamae Mitsuhiro, Yamada Makiko

Psychological Reports (2024-09)

DOI
In Vivo Assessment of Astrocyte Reactivity in Patients with Progressive Supranuclear Palsy.

Kosei Hirata, Kiwamu Matsuoka, Kenji Tagai, Hironobu Endo, Harutsugu Tatebe, Maiko Ono, Naomi Kokubo, Yuko Kataoka, Asaka Oyama, Hitoshi Shinotoh, Keisuke Takahata, Takayuki Obata, Masoumeh Dehghani, Jamie Near, Kazunori Kawamura, Ming-Rong Zhang, Hitoshi Shimada, Hiroshi Shimizu, Akiyoshi Kakita, Takanori Yokota, Takahiko Tokuda, Makoto Higuchi, Yuhei Takado

Annals of neurology, 96(2): 247–261 (2024-08)

DOI
Distinct roles of monkey OFC-subcortical pathways in adaptive behavior

Kei Oyama, Kei Majima, Yuji Nagai, Yukiko Hori, Toshiyuki Hirabayashi, Mark A G Eldridge, Koki Mimura, Naohisa Miyakawa, Atsushi Fujimoto, Yuki Hori, Haruhiko Iwaoki, Ken-Ichi Inoue, Richard C Saunders, Masahiko Takada, Noriaki Yahata, Makoto Higuchi, Barry J Richmond, Takafumi Minamimoto

Nature Communications (2024-08)

DOI
Effects of a 5-HT4 receptor antagonist in the caudate nucleus on the performance of macaques in a delayed reward task

Hori Yukiko, Iwaoki Haruhiko, Mimura Koki, Nagai Yuji, Higuchi Makoto, Minamimoto Takafumi

Scientific reports, 14: 19619 (2024-08)

DOI
Multiscale chemogenetic dissection of fronto-temporal top-down regulation for object memory in primates.

Toshiyuki Hirabayashi, Yuji Nagai, Yuki Hori, Yukiko Hori, Kei Oyama, Koki Mimura, Naohisa Miyakawa, Haruhiko Iwaoki, Ken-Ichi Inoue, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Takafumi Minamimoto

Nature communications, 15(1): 5369 (2024-07)

DOI
descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques

Kohei Otomo, Takaki Omura, Yuki Nozawa, Steven J. Edwards, Yukihiko Sato, Yuri Saito, Shigehiro Yagishita, Hitoshi Uchida, Yuki Watakabe, Kiyotada Naitou, Rin Yanai, Naruhiko Sahara, Satoshi Takagi, Ryohei Katayama, Yusuke Iwata, Toshiro Shiokawa, Yoku Hayakawa, Kensuke Otsuka, Haruko Watanabe-Takano, Yuka Haneda, Shigetomo Fukuhara, Miku Fujiwara, Takenobu Nii, Chikara Meno, Naoki Takeshita, Kenta Yashiro, Juan Marcelo Rosales Rocabado, Masaru Kaku, Tatsuya Yamada, Yumiko Oishi, Hiroyuki Koike, Yinglan Cheng, Keisuke Sekine, Jun-ichiro Koga, Kaori Sugiyama, Kenichi Kimura, Fuyuki Karube, Hyeree Kim, Ichiro Manabe, Tomomi Nemoto, Kazuki Tainaka, Akinobu Hamada, Hjalmar Brismar, Etsuo A. Susaki

Nature Communications, 15: 4941 (2024-06)

DOI
DOCK–PET: database of CNS kinetic parameters in the healthy human brain for existing PET tracers

Itsuki Miyajima, Ayano Yoshikawa, Kyosei Sahashi, Seki Chie, Nagai Yuji, Watabe Hiroshi, Shidahara Miho

Annals of Nuclear Medicine (2024-05)

DOI
Imaging α-synuclein pathologies in animal models and patients with Parkinson's and related diseases.

Hironobu Endo, Maiko Ono, Yuhei Takado, Kiwamu Matsuoka, Manami Takahashi, Kenji Tagai, Yuko Kataoka, Kosei Hirata, Keisuke Takahata, Chie Seki, Naomi Kokubo, Masayuki Fujinaga, Wakana Mori, Yuji Nagai, Koki Mimura, Katsushi Kumata, Tatsuya Kikuchi, Aki Shimozawa, Sushil K Mishra, Yoshiki Yamaguchi, Hiroshi Shimizu, Akiyoshi Kakita, Hiroyuki Takuwa, Hitoshi Shinotoh, Hitoshi Shimada, Yasuyuki Kimura, Masanori Ichise, Tetsuya Suhara, Takafumi Minamimoto, Naruhiko Sahara, Kazunori Kawamura, Ming-Rong Zhang, Masato Hasegawa, Makoto Higuchi

Neuron (2024-05)

DOI
Amyloid-β prediction machine learning model using source-based morphometry across neurocognitive disorders.

Yuki Momota, Shogyoku Bun, Jinichi Hirano, Kei Kamiya, Ryo Ueda, Yu Iwabuchi, Keisuke Takahata, Yasuharu Yamamoto, Toshiki Tezuka, Masahito Kubota, Morinobu Seki, Ryo Shikimoto, Yu Mimura, Taishiro Kishimoto, Hajime Tabuchi, Masahiro Jinzaki, Daisuke Ito, Masaru Mimura

Scientific reports, 14(1): 7633 (2024-04)

DOI
Neural responses to gaming content on social media in young adults.

Yuka Fujimoto, Junya Fujino, Daisuke Matsuyoshi, Daisuke Jitoku, Nanase Kobayashi, Chenyu Qian, Shoko Okuzumi, Shisei Tei, Takehiro Tamura, Takefumi Ueno, Makiko Yamada, Hidehiko Takahashi

Behavioural brain research, 467: 115004 (2024-04)

DOI
In vivo PET classification of tau pathologies in patients with frontotemporal dementia

Manabu Kubota, Hironobu Endo, Keisuke Takahata, Kenji Tagai, Hisaomi Suzuki, Mitsumoto Onaya, Yasunori Sano, Yasuharu Yamamoto, Shin Kurose, Kiwamu Matsuoka, Chie Seki, Hitoshi Shinotoh, Kazunori Kawamura, Ming-Rong Zhang, Yuhei Takado, Hitoshi Shimada, Makoto Higuchi

Brain communications, 6(2): fcae075 (2024-03)

DOI
Overlapping yet dissociable contributions of superiority illusion features to Ponzo illusion strength and metacognitive performance

Matsuyoshi Daisuke, Isato Ayako, Yamada Makiko

BMC Psychology, 12: 108 (2024-03)

DOI
Late-life mood disorder as the initial presentation of progressive supranuclear palsy: A case series

Takahata Keisuke, Kurose Shin, Endo Hironobu, Tagai Kenji, Higuchi Makoto

Psychiatry and Clinical Neurosciences Reports, 3(1): e178 (2024-03)
Metallic radionuclide-labeled tetrameric 2,6-diisopropylphenyl azides for cancer treatment.

Yudai Ode, Ambara R Pradipta, Akihiro Ishiwata, Akihiro Nambu, Kazunobu Ohnuki, Hiroshi Mizuma, Hiromitsu Haba, Katsunori Tanaka

Chemical communications (Cambridge, England), 60(24): 3291–3294 (2024-03)

DOI
Association between mammillary body atrophy and memory impairment in retired athletes with a history of repetitive mild traumatic brain injury.

Mari Miyata, Keisuke Takahata, Yasunori Sano, Yasuharu Yamamoto, Shin Kurose, Manabu Kubota, Hironobu Endo, Kiwamu Matsuoka, Kenji Tagai, Masaki Oya, Kosei Hirata, Fumie Saito, Masaru Mimura, Koji Kamagata, Shigeki Aoki, Makoto Higuchi

Scientific reports, 14(1): 7129 (2024-03)

DOI
Research on the molecular mechanism of singularity phenomenon in neurological disorders.

Hiroko Bannai, Akihiko Takashima, Yoshiyuki Soeda, Hideaki Yoshimura, Gen Matsumoto, Naruhiko Sahara, Michio Hiroshima, Mitsuru Hattori, Takeharu Nagai

Biophysics and physicobiology, 21 (2024-02)

DOI
Diagnostic and therapeutic targeting of pathological tau proteins in neurodegenerative disorders.

Naruhiko Sahara, Makoto Higuchi

FEBS open bio, 14(2): 165–180 (2024-02)

DOI
Imaging-based chemogenetics for dissecting neural circuits in nonhuman primates.

Takafumi Minamimoto, Yuji Nagai, Kei Oyama

Proceedings of the Japan Academy. Series B, Physical and biological sciences, 100(8): 476–489 (2024-01)
Reduced serotonergic transmission alters sensitivity to cost and reward via 5-HT1A and 5-HT1B receptors in monkeys.

Yukiko Hori, Koki Mimura, Yuji Nagai, Yuki Hori, Katsushi Kumata, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi, Takafumi Minamimoto

PLoS biology, 22(1): e3002445 (2024-01)

DOI
An intra-oral flavor detection task in freely moving mice

Shiotani Kazuki, Tanisumi Yuta, Osako Yuma, Murata Koshi, Hirokawa Junya, Sakurai Yoshio, Manabe Hiroyuki

iScience, 27(2): 108924 (2024-01)

DOI
Validation of a newly developed immunoassay for TDP-43 in human plasma

Matsuura Sayo, Tatebe Harutsugu, Higuchi Makoto, Tokuda Takahiko

Heliyon, 10(2): e24672 (2024-01)

DOI
Explicit and implicit effects of gaming content on social media on the behavior of young adults

Daisuke Jitoku, Nanase Kobayashi, Yuka Fujimoto, Chenyu Qian, Shoko Okuzumi, Shisei Tei, Daisuke Matsuyoshi, Takehiro Tamura, Hidehiko Takahashi, Takefumi Ueno, Makiko Yamada, Junya Fujino

Frontiers in psychology, 15: 1332462 (2024-01)

DOI

2023

Targeted Delivery of Chemogenetic Adeno-Associated Viral Vectors to Cortical Sulcus Regions in Macaque Monkeys by Handheld Injections

Oyama Kei, Nagai Yuji, Minamimoto Takafumi

Bio-protocol, 13(23): e4897 (2023-12)

DOI
Chemogenetics for cell-type specific modulation of signaling and neuronal activity.

Hye Jin Kang, Minamimoto Takafumi, Jürgen Wess, Bryan L. Roth

Nature Reviews Methods Primers, 3: 93 (2023-12)

DOI
Performance of plasma Aβ42/40, measured using a fully automated immunoassay, across a broad patient population in identifying amyloid status

Takahata Keisuke, Kurose Shin, Mimura Yu, Moriguchi Sho, Momota Yuki

Alzheimer's research and therapy, 15: 149 (2023-12)

DOI
Radiation dosimetry and pharmacokinetics of the tau PET tracer florzolotau (18F) in healthy Japanese subjects

Takahata Keisuke

Annals of nuclear medicine, 37(5): 300–309 (2023-12)

DOI
Development of Contextual-dependent Optimism Task: A Longitudinal Study of Influences of the Pandemic on Optimistic Predictions.

Isato Ayako, Aizawa Yasunori, Miyamae Mitsuhiro, Yamada Makiko

PsyArXiv (2023-12)
Investigating neural dysfunction with abnormal protein deposition in Alzheimer's disease through magnetic resonance spectroscopic imaging, plasma biomarkers, and positron emission tomography.

Kiwamu Matsuoka, Kosei Hirata, Naomi Kokubo, Takamasa Maeda, Kenji Tagai, Hironobu Endo, Keisuke Takahata, Hitoshi Shinotoh, Maiko Ono, Chie Seki, Harutsugu Tatebe, Kazunori Kawamura, Ming-Rong Zhang, Hitoshi Shimada, Takahiko Tokuda, Makoto Higuchi, Yuhei Takado

NeuroImage. Clinical, 41: 103560 (2023-12)

DOI
Association of Tooth Loss with Alzheimer's Disease Tau Pathologies Assessed by Positron Emission Tomography.

Hideki Matsumoto, Kenji Tagai, Hironobu Endo, Kiwamu Matsuoka, Yuhei Takado, Naomi Kokubo, Hitoshi Shimada, Tetsuya Goto, Tazuko K Goto, Makoto Higuchi

Journal of Alzheimer's disease : JAD, 96(3): 1253–1265 (2023-11)

DOI
PET reporter systems for the brain.

Sridhar Goud Nerella, Michael Michaelides, Takafumi Minamimoto, Robert B Innis, Victor W Pike, Mark A G Eldridge

Trends in neurosciences, 46(11): 941–952 (2023-11)

DOI
Synthesis and evaluation of a novel PET ligand, a GSK'963 analog, aiming at autoradiography and imaging of the receptor interacting protein kinase 1 in the brain.

Hiroshi Ikenuma, Aya Ogata, Hiroko Koyama, Bin Ji, Hideki Ishii, Takashi Yamada, Junichiro Abe, Chie Seki, Yuji Nagai, Masanori Ichise, Takafumi Minamimoto, Makoto Higuchi, Ming-Rong Zhang, Takashi Kato, Kengo Ito, Masaaki Suzuki, Yasuyuki Kimura

EJNMMI radiopharmacy and chemistry, 8(1): 31 (2023-10)

DOI
Multimodal imaging for validation and optimization of ion channel-based chemogenetics in nonhuman primates.

Yuki Hori, Yuji Nagai, Yukiko Hori, Kei Oyama, Koki Mimura, Toshiyuki Hirabayashi, Ken-Ichi Inoue, Masayuki Fujinaga, Ming-Rong Zhang, Masahiko Takada, Makoto Higuchi, Takafumi Minamimoto

The Journal of neuroscience, 43(39): 6619–6627 (2023-09)

DOI
Altered Brain Energy Metabolism Related to Astrocytes in Alzheimer's Disease.

Kosei Hirata, Kiwamu Matsuoka, Kenji Tagai, Hironobu Endo, Harutsugu Tatebe, Maiko Ono, Naomi Kokubo, Asaka Oyama, Hitoshi Shinotoh, Keisuke Takahata, Takayuki Obata, Masoumeh Dehghani, Jamie Near, Kazunori Kawamura, Ming-Rong Zhang, Hitoshi Shimada, Takanori Yokota, Takahiko Tokuda, Makoto Higuchi, Yuhei Takado

Annals of neurology, 95(1): 104–115 (2023-09)

DOI
Contingency adduction を用いた視覚的な点字学習法

小原健一郎, 大島研介, 相澤裕紀

Japanese Journal of Behavior Analysis, 38(1): 16–26 (2023-09)

DOI
Tumour status prediction by means of carbon-ion beam irradiation: comparison of washout rates between in-beam PET and DCE-MRI in rats

Toramatsu Chie, Akram Mohammadi, Wakizaka Hidekatsu, Nitta Nobuhiro, Ikoma Yoko, Seki Chie, Kanno Iwao, Yamaya Taiga

Physics in Medicine & Biology, 68(19): 195005-1–195005-12 (2023-09)

DOI
Digital Motor Biomarkers of Cerebellar Ataxia Using an RGB-Depth Camera-Based Motion Analysis System.

Masahide Suzuki, Shigeki Hirano, Karen Otte, Tanja Schmitz-Hübsch, Michiko Izumi, Mitsuyoshi Tamura, Ryota Kuroiwa, Atsuhiko Sugiyama, Masahiro Mori, Hanna M Röhling, Alexander U Brandt, Atsushi Murata, Friedemann Paul, Satoshi Kuwabara

Cerebellum (London, England), 23: 1031–1041 (2023-09)

DOI
Association of protein distribution and gene expression revealed by positron emission tomography and postmortem gene expression in the dopaminergic system of the human brain.

Yasuharu Yamamoto, Keisuke Takahata, Manabu Kubota, Hiroyoshi Takeuchi, Sho Moriguchi, Takeshi Sasaki, Chie Seki, Hironobu Endo, Kiwamu Matsuoka, Kenji Tagai, Yasuyuki Kimura, Shin Kurose, Masaru Mimura, Kazunori Kawamura, Ming-Rong Zhang, Makoto Higuchi

European journal of nuclear medicine and molecular imaging, 50: 3928–3936 (2023-08)

DOI
A mosaic adeno-associated virus vector as a versatile tool that exhibits high levels of transgene expression and neuron specificity in primate brain.

Kei Kimura, Yuji Nagai, Gaku Hatanaka, Yang Fang, Soshi Tanabe, Andi Zheng, Maki Fujiwara, Mayuko Nakano, Yukiko Hori, Ryosuke F Takeuchi, Mikio Inagaki, Takafumi Minamimoto, Ichiro Fujita, Ken-Ichi Inoue, Masahiko Takada

Nature communications, 14: 4762 (2023-08)

DOI
CenTauR: Toward a universal scale and masks for standardizing tau imaging studies.

Victor L Villemagne, Antoine Leuzy, Sandra Sanabria Bohorquez, Santiago Bullich, Hitoshi Shimada, Christopher C Rowe, Pierrick Bourgeat, Brian Lopresti, Kun Huang, Natasha Krishnadas, Jurgen Fripp, Yuhei Takado, Alexandra Gogola, Davneet Minhas, Robby Weimer, Makoto Higuchi, Andrew Stephens, Oskar Hansson, Vincent Doré

Alzheimer's & dementia (Amsterdam, Netherlands), 15(3): e12454 (2023-07)

DOI
Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism.

Masaki Oya, Kiwamu Matsuoka, Manabu Kubota, Junya Fujino, Shisei Tei, Keisuke Takahata, Kenji Tagai, Yasuharu Yamamoto, Hitoshi Shimada, Chie Seki, Takashi Itahashi, Yuta Y Aoki, Haruhisa Ohta, Ryu-Ichiro Hashimoto, Genichi Sugihara, Takayuki Obata, Ming-Rong Zhang, Tetsuya Suhara, Motoaki Nakamura, Nobumasa Kato, Yuhei Takado, Hidehiko Takahashi, Makoto Higuchi

Scientific reports, 13(1): 11655 (2023-07)

DOI
Association between enhanced carbonyl stress and decreased apparent axonal density in schizophrenia by multimodal white matter imaging

Shuraku Son, Makoto Arai, Kazuya Toriumi, Christina Andica, Daisuke Matsuyoshi, Koji Kamagata, Shigeki Aoki, Takahiko Kawashima, Takanori Kochiyama, Tomohisa Okada, Yasutaka Fushimi, Yuji Nakamoto, Yuko Kobayashi, Toshiya Murai, Masanari Itokawa, Jun Miyata

Scientific Reports, 13: 12220 (2023-07)

DOI
Assessing late-life anxiety in Japanese older adults: psychometric evaluation of the Japanese version of the Geriatric Anxiety Scale.

Masami Kashimura, Kenichiro Ishizu, Naomi Kokubo, Daniel L Segal

Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 23(4): 631–641 (2023-07)

DOI
The Japan Monkey Centre Primates Brain Imaging Repository of high-resolution postmortem magnetic resonance imaging: The second phase of the archive of digital records.

Tomoko Sakai, Junichi Hata, Yuta Shintaku, Hiroki Ohta, Kazumi Sogabe, Susumu Mori, Takako Miyabe-Nishiwaki, Hirotaka James Okano, Yuzuru Hamada, Toshiyuki Hirabayashi, Takafumi Minamimoto, Norihiro Sadato, Hideyuki Okano, Kenichi Oishi

NeuroImage, 273: 120096 (2023-06)

DOI
Serotonergic neurotransmission in limbic regions may reflect therapeutic response of depressive patients: A PET study with 11C-WAY-100635 and 18F-MPPF.

Soichiro Kitamura, Yasuyuki Kimura, Keisuke Takahata, Sho Moriguchi, Manabu Kubota, Hitoshi Shimada, Hironobu Endo, Yuhei Takado, Kazunori Kawamura, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi

The international journal of neuropsychopharmacology, 26(7): 474–482 (2023-06)

DOI
Stable Neural Population Dynamics in the Regression Subspace for Continuous and Categorical Task Parameters in Monkeys.

He Chen, Jun Kunimatsu, Tomomichi Oya, Yuri Imaizumi, Yukiko Hori, Masayuki Matsumoto, Takafumi Minamimoto, Yuji Naya, Hiroshi Yamada

eNeuro, 10(7): 0016-23 (2023-06)

DOI
Quantification of monoacylglycerol lipase and its occupancy by an exogenous ligand in rhesus monkey brains using [18F]T-401 and PET

Yasushi Hattori, Seki Chie, Maeda Jun, Nagai Yuji, Kazunobu Aoyama, Zhang Ming-Rong, Minamimoto Takafumi, Tatsuki Koike, Higuchi Makoto

Journal of Cerebral Blood Flow & Metabolism, 42(4): 656–666 (2023-05)

DOI
Ultrahigh resolution small animal positron emission tomography

Hangyu Kang, Tashima Hideaki, Wakizaka Hidekatsu, Nishikido Fumihiko, Higuchi Makoto, Takahashi Miwako, Yamaya Taiga

JSMI Report Vol. 16, No. 2, 6(2): 6–9 (2023-05)
11C-Labeling of acyclic retinoid peretinoin by rapid C-[11C]methylation to disclose novel brain permeability and central nervous system activities hidden in antitumor agent

Keiichi Suzuki, Koyama Hiroko, Narumasa Nakamura, Kimura Yasuyuki, Aya Ogata, Hiroshi Ikenuma, Ishii Hideki, Zhang Ming-Rong, Kawamura Kazunori, Minamimoto Takafumi, Nagai Yuji, Hiroshi Katsuki, Tetsuya Kimura, Nobuyuki Kimura, Ichise Masanori, Takashi Kato, Kengo Ito, Masaaki Suzuki

Bioorganic & Medicinal Chemistry Letters, 85: 129212 (2023-04)

DOI
Limitations of human tau-expressing mouse models and novel approaches of mouse modeling for tauopathy.

Naruhiko Sahara, Rin Yanai

Frontiers in Neuroscience, 17: 1149761 (2023-04)

DOI
Impact of Amyloid and Tau PET on Changes in Diagnosis and Patient Management

Sho Shimohama, Toshiki Tezuka, Takahata Keisuke, Shogyoku Bun, Hajime Tabuchi, Morinobu Seki, Yuki Momota, Natsumi Suzuki, Ayaka Morimoto, Yu Iwabuchi, Masahito Kubota, Yasuharu Yamamoto, Yasunori Sano, Ryo Shikimoto, Kei Funaki, Mimura Yu, Yoshinori Nishimoto, Ryo Ueda, Masahiro Jinzaki, Jin Nakahara, Masaru Mimura, Daisuke Ito

Neurology, 100(3): e263–e274 (2023-03)

DOI
Are colour experiences the same across the visual field?

Ariel Zeleznikow-Johnston, Aizawa Yasunori, Yamada Makiko, Naotsugu Tsuchiya

Journal of Cognitive Neuroscience, 35(4): 509–542 (2023-03)

DOI
Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model

Kudo Takehiro, Takuwa Hiroyuki, Manami Takahashi, Urushihata Takuya, Shimojo Masafumi, Kazuaki Sampei, Mitsugu Yamanaka, Tomita Yutaka, Sahara Naruhiko, Suhara Tetsuya, Higuchi Makoto

iScience, 26(4): 106342 (2023-03)

DOI
Capillary responses to functional and pathological activations rely on the capillary states at rest.

Hiroki Suzuki, Hiroshi Takeda, Hiroyuki Takuwa, Bin Ji, Makoto Higuchi, Iwao Kanno, Kazuto Masamoto

Journal of cerebral blood flow and metabolism, 43(6): 1010–1024 (2023-02)

DOI
Chemogenetic attenuation of cortical seizures in nonhuman primates.

Naohisa Miyakawa, Yuji Nagai, Yukiko Hori, Koki Mimura, Asumi Orihara, Kei Oyama, Takeshi Matsuo, Ken-Ichi Inoue, Takafumi Suzuki, Toshiyuki Hirabayashi, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Keisuke Kawasaki, Takafumi Minamimoto

Nature communications, 14: 971 (2023-02)

DOI
Two pathways differentially linking tau depositions, oxidative stress, and neuronal loss to apathetic phenotypes in progressive supranuclear palsy

Matsuoka Kiwamu, Takado Yuhei, Tagai Kenji, Kubota Manabu, Sano Yasunori, Takahata Keisuke, Ono Maiko, Seki Chie, Matsumoto Hideki, Endo Hironobu, Shinotoh Hitoshi, Sahara Yasuka, Obata Takayuki, Jamie Near, Kawamura Kazunori, Zhang Ming-Rong, Suhara Tetsuya, Shimada Hitoshi, Higuchi Makoto

Journal of the Neurological Sciences, 444: 120514 (2023-01)

DOI
Synthesis and structure–activity relationship (SAR) studies of 1,2,3-triazole, amide, and ester-based benzothiazole derivatives as potential molecular probes for tau protein

Hendris Wongso, Ono Maiko, Yamasaki Tomoteru, Kumata Katsushi, Higuchi Makoto, Zhang Ming-Rong, Michael J. Fulham, Andrew Katsifis, Paul A. Keller

RSC Medicinal Chemistry, 14(5): 858–868 (2023-01)

DOI
Distribution of intraperitoneally administered D2O in AQP4-knockout mouse brain after MCA occlusion

Urushihata Takuya, Takuwa Hiroyuki, Takahashi Manami, Jeffrey Kershaw, Shibata Sayaka, Nitta Nobuhiro, Tachibana Yasuhiko, Yasui Masato, Higuchi Makoto, Obata Takayuki

Frontiers in Neuroscience, 16: 1071272 (2023-01)

DOI

2022

Multimodal analyses of a non-human primate model harboring mutant amyloid precursor protein transgenes driven by the human EF1α promoter

Sho Yoshimatsu, Fumiko Seki, Junko Okahara, Hirotaka Watanabe, Hiroki Sasaguri, Yawara Haga, Jun-ichi Hata, Tsukasa Sanosaka, Takashi Inoue, Takayuki Mineshige, Chia-Ying Lee, Haruka Shinohara, Yoko Kurotaki, Yuji Komaki, Noriyuki Kishi, Ayaka Y. Murayama, Nagai Yuji, Minamimoto Takafumi, Masafumi Yamamoto, Mayutaka Nakajima, Zhi Zhou, Akisa Nemoto, Tsukika Sato, Takeshi Ikeuchi, Sahara Naruhiko, Satoru Morimoto, Seiji Shiozawa, Takaomi C. Saido, Erika Sasaki, Hideyuki Okano

Neuroscience Research, 185: 49–61 (2022-12)

DOI
An optimized reference tissue method for quantification of tau protein depositions in diverse neurodegenerative disorders by PET with 18F-PM-PBB3 (18F-APN-1607)

Tagai Kenji, Ikoma Yoko, Hironobu Endo, Oiendrila Bhowmik Debnath, Seki Chie, Matsuoka Kiwamu, Matsumoto Hideki, Oya Masaki, Hirata Kosei, Shinotoh Hitoshi, Takahata Keisuke, Kurose Shin, Sano Yasunori, Ono Maiko, Shimada Hitoshi, Kawamura Kazunori, Zhang Ming-Rong, Takado Yuhei, Higuchi Makoto

NeuroImage, 264: 119763 (2022-12)

DOI
Findings of 18 F-PI-2620 tau PET imaging in patients with Alzheimer's disease and healthy controls in relation to the plasma P-tau181 levels in a Japanese sample

Shogyoku Bun, Sho Moriguchi, Toshiki Tezuka, Yoshiaki Sato, Keisuke Takahata, Morinobu Seki, Shinichiro Nakajima, Yasuharu Yamamoto, Yasunori Sano, Natsumi Suzuki, Ayaka Morimoto, Ryo Ueda, Hajime Tabuchi, Daisuke Ito, Masaru Mimura

Neuropsychopharmacology Reports, 42(4): 437–448 (2022-12)

DOI
Submillimeter resolution positron emission tomography for high-sensitivity mouse brain imaging

Hangyu Kang, Tashima Hideaki, Wakizaka Hidekatsu, Nishikido Fumihiko, Higuchi Makoto, Takahashi Miwako, Yamaya Taiga

The Journal of Nuclear Medicine, 64(6): 978–985 (2022-12)

DOI
Positron Emission Tomography Assessments of Phosphodiesterase 10A in Patients With Schizophrenia.

Manabu Kubota, Keisuke Takahata, Kiwamu Matsuoka, Yasunori Sano, Yasuharu Yamamoto, Kenji Tagai, Ryosuke Tarumi, Hisaomi Suzuki, Shin Kurose, Shinichiro Nakajima, Hiroki Shiwaku, Chie Seki, Kazunori Kawamura, Ming-Rong Zhang, Hidehiko Takahashi, Yuhei Takado, Makoto Higuchi

Schizophrenia bulletin, 49(3): 688–696 (2022-12)

DOI
A Machine Learning–Based Approach to Discrimination of Tauopathies Using [18F]PM-PBB3 PET Images

Endo Hironobu, Tagai Kenji, Ono Maiko, Ikoma Yoko, Oyama Asaka, Matsuoka Kiwamu, Kokubo Naomi, Hirata Kosei, Sano Yasunori, Oya Masaki, Matsumoto Hideki, Kurose Shin, Seki Chie, Hiroshi Shimizu, Akiyoshi Kakita, Takahata Keisuke, Shinoto Hitoshi, Shimada Hitoshi, Tokuda Takahiko, Kawamura Kazunori, Zhang Ming-Rong, Kenichi Oishi, Susumu Mori, Takado Yuhei, Higuchi Makoto

Movement Disorders, 37(11): 2236–2246 (2022-11)

DOI
Case report: Non-Alzheimer's disease tauopathy with logopenic variant primary progressive aphasia diagnosed using amyloid and tau PET

Takahata Keisuke, Momota Yuki, Mika Konishi, Taishiro Kishimoto, Tezuka Toshiki, Shogyoku Bun, Hajime Tabuchi, Daisuke Ito, Masaru Mimura

Frontiers in neurology, 13: 1049113 (2022-11)

DOI
Soluble TREM2 and Alzheimer-related biomarker trajectories in the blood of patients with diabetes based on their cognitive status.

Noriko Satoh-Asahara, Hajime Yamakage, Masashi Tanaka, Teruaki Kawasaki, Sayo Matsuura, Harutsugu Tatebe, Ichiro Akiguchi, Takahiko Tokuda

Diabetes research and clinical practice, 193: 110121 (2022-11)

DOI
High-Contrast Imaging of α-Synuclein Pathologies in Living Patients with Multiple System Atrophy

Kiwamu Matsuoka, Maiko Ono, Yuhei Takado, Kosei Hirata, Hironobu Endo, Toshiyuki Ohfusa, Taichi Kojima, Takeshi Yamamoto, Tomohiro Onishi, Asumi Orihara, Kenji Tagai, Keisuke Takahata, Chie Seki, Hitoshi Shinotoh, Kazunori Kawamura, Hiroshi Shimizu, Hitoshi Shimada, Akiyoshi Kakita, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi

Movement disorders : official journal of the Movement Disorder Society, 37(10): 2159–2161 (2022-10)

DOI
Chemogenetic Disconnection between the Orbitofrontal Cortex and the Rostromedial Caudate Nucleus Disrupts Motivational Control of Goal-Directed Action

Kei Oyama, Yukiko Hori, Koki Mimura, Yuji Nagai, Mark A G Eldridge, Richard C Saunders, Naohisa Miyakawa, Toshiyuki Hirabayashi, Yuki Hori, Ken-Ichi Inoue, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Barry J Richmond, Takafumi Minamimoto

The Journal of neuroscience, 42(32): 6267–6275 (2022-08)

DOI
Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model

Arata Oh-Nishi, Nagai Yuji, Seki Chie, Suhara Tetsuya, Minamimoto Takafumi, Higuchi Makoto

Brain, Behavior, & Immunity - Health, 22: 100446 (2022-07)

DOI
Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy

Ono Maiko, Masaaki Komatsu, Bin Ji, Takado Yuhei, Shimojo Masafumi, Minamihisamatsu Takeharu, Eiji Warabi, Toru Yanagawa, Gen Matsumoto, Aoki Ichio, Nicholas M. Kanaan, Suhara Tetsuya, Sahara Naruhiko, Higuchi Makoto

Aging Cell, 21(7): e13615 (2022-07)

DOI
A quantitative in vivo imaging platform for tracking pathological tau depositions and resultant neuronal death in a mouse model

Taeko Kimura, Ono Maiko, Seki Chie, Kazuaki Sampei, Shimojo Masafumi, Kawamura Kazunori, Zhang Ming-Rong, Sahara Naruhiko, Takado Yuhei, Higuchi Makoto

European Journal of Nuclear Medicine and Molecular Imaging, 49(13): 4298–4311 (2022-07)

DOI
Measurement of Striatal Dopamine Release Induced by Neuropsychological Stimulation in Positron Emission Tomography with Dual Injections of [11C]Raclopride

Ikoma Yoko, Kimura Yasuyuki, Yamada Makiko, Obata Takayuki, Suhara Tetsuya, Ito Hiroshi

Frontiers in Psychiatry, 13: 811136 (2022-07)

DOI
Measurement of biological washout rates depending on tumor vascular status in 15O in-beam rat-PET

Toramatsu Chie, Akram Mohammadi, Wakizaka Hidekatsu, Sudo Hitomi, Nitta Nobuhiro, Seki Chie, Takahashi Miwako, Kanno Iwao, Karasawa Kumiko, Hirano Yoshiyuki, Yamaya Taiga

Physics in Medicine & Biology, 67: 125006 (2022-06)

DOI
Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice

Yuriko Tachida, Saori Miura, Yui Muto, Takuwa Hiroyuki, Naruhiko Sahara, Akihiro Shindo, Yukio Matsuba, Takashi Saito, Naoyuki Taniguchi, Yasushi Kawaguchi, Hidekazu Tomimoto, Takaomi Saido, Shinobu Kitazume

Journal Impact IF of Journal of Biological Chemistry, 298(6): 101880 (2022-06)

DOI
PET-based classification of corticobasal syndrome

Yoshikazu Nakano, Hitoshi Shimada, Hitoshi Shinotoh, Shigeki Hirano, Kenji Tagai, Yasunori Sano, Yasuharu Yamamoto, Hironobu Endo, Kiwamu Matsuoka, Keisuke Takahata, Manabu Kubota, Yuhei Takado, Yasuyuki Kimura, Masanori Ichise, Maiko Ono, Naruhiko Sahara, Kazunori Kawamura, Ming-Rong Zhang, Satoshi Kuwabara, Tetsuya Suhara, Makoto Higuchi

Parkinsonism & related disorders, 98(1): 92–98 (2022-05)

DOI
Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology.

Koyo Tsujikawa, Kohei Hamanaka, Yuichi Riku, Yuki Hattori, Norikazu Hara, Yohei Iguchi, Shinsuke Ishigaki, Atsushi Hashizume, Satoko Miyatake, Satomi Mitsuhashi, Yu Miyazaki, Mayumi Kataoka, Li Jiayi, Keizo Yasui, Satoshi Kuru, Haruki Koike, Kenta Kobayashi, Naruhiko Sahara, Norio Ozaki, Mari Yoshida, Akiyoshi Kakita, Yuko Saito, Yasushi Iwasaki, Akinori Miyashita, Takeshi Iwatsubo, Takeshi Ikeuchi, Takaki Miyata, Gen Sobue, Naomichi Matsumoto, Kentaro Sahashi, Masahisa Katsuno

Science advances, 8(21): eabm5029 (2022-05)

DOI
Correction to: First‐in‐human in vivo imaging and quantification of monoacylglycerol lipase in the brain: a PET study with 18F‐T‐401

Keisuke Takahata, Chie Seki, Yasuyuki Kimura, Manabu Kubota, Masanori Ichise, Yasunori Sano, Yasuharu Yamamoto, Kenji Tagai, Hitoshi Shimada, Soichiro Kitamura, Kiwamu Matsuoka, Hironobu Endo, Hitoshi Shinotoh, Kazunori Kawamura, Ming-Rong Zhang, Yuhei Takado, Makoto Higuchi

European journal of nuclear medicine and molecular imaging, 49(9): 3299 (2022-04)

DOI
Chronic behavioral manipulation via orally delivered chemogenetic actuator in macaques

Oyama Kei, Hori Yukiko, Nagai Yuji, Miyakawa Naohisa, Mimura Koki, Hirabayashi Toshiyuki, Ken-ichi Inoue, Masahiko Takada, Higuchi Makoto, Minamimoto Takafumi

Journal of Neuroscience, 42(12): 2552–2561 (2022-03)

DOI
Efficacy of the unified protocol for transdiagnostic cognitive-behavioral treatment for depressive and anxiety disorders: a randomized controlled trial

Masaya Ito, Masaru Horikoshi, Noriko Kato, Yuki Oe, Hiroko Fujisato, Keiko Yamaguchi, Shun Nakajima, Miyamae Mitsuhiro, Ayaka Toyota, Yasuyuki Okumura, Yoshitake Takebayashi

Psychological Medicine (2022-03)

DOI
Progressive Ataxia and Palatal Tremor Showing Characteristic Tau Depositions in [18F]PM-PBB3 PET

Toshiki Tezuka, Keisuke Takahata, Kenji Tagai, Ryo Ueda, Daisuke Ito, Hidetaka Takeda, Shinichi Takahashi, Jin Nakahara, Makoto Higuchi, Morinobu Seki

Movement disorders : official journal of the Movement Disorder Society, 37(6): 1317–1319 (2022-03)

DOI
Loss of causes sterility due to impaired spermatid differentiation in mice.

Yuki Hiradate, Ryua Harima, Rin Yanai, Kenshiro Hara, Kazue Nagasawa, Makoto Osada, Tomoe Kobayashi, Makoto Matsuyama, Shin-Ichiro Kanno, Akira Yasui, Kentaro Tanemura

Reproductive medicine and biology, 21(1): e12452 (2022-03)

DOI
Comparison of MRI-based and PET-based image pre-processing for quantification of 11C-PBB3 uptake in human brain

Elham Yousefzadeh-Nowshahr, Gordon Winter, Peter Bohn, Katharina Kneer, Christine A.F. von Arnim, Markus Otto, Christoph Solbach, Sarah Anderl-Straub, Dörte Polivka, Patrick Fissler, Vikas Prasad, Peter Kletting, Matthias W. Riepe, Higuchi Makoto, Albert Ludolph, Ambros J. Beer, Gerhard Glatting

Zeitschrift für Medizinische Physik, 31(1): 37–47 (2022-02)

DOI
Automated radiosynthesis of [11C]MTP38—a phosphodiesterase 7 imaging tracer—using [11C]hydrogen cyanide for clinical applications

Kawamura Kazunori, Hashimoto Hiroki, Takayuki Ohkubo, Hanyu Masayuki, Ogawa Masanao, Nengaki Nobuki, Arashi Daisuke, Yusuke Kurihara, Tomoya Fujishiro, Takahiro Togashi, Toshiyuki Sakai, Muto Masatoshi, Takei Makoto, Ishii Hideki, Saijo Takeaki, Matsumura Takehiko, Obokata Naoyuki, Zhang Ming-Rong

Journal of Labelled Compounds and Radiopharmaceuticals, 65(5): 140–146 (2022-02)

DOI
Neural network of superiority illusion predicts the level of dopamine in striatum

Yahata Noriaki, Isato Ayako, Kimura Yasuyuki, Yokokawa Keita, Zhang Ming-Rong, Hiroshi Ito, Suhara Tetsuya, Higuchi Makoto, Yamada Makiko

bioRχiv (2022-02)

DOI
Symptom Changes in Patients with Pre-existing Psychiatric Disorders in the Initial Phase of the COVID-19 Pandemic: Vulnerability of Female Patients and Patients with Mood Disorders

Kurose Shin, Michitaka Funayama, Takata Taketo, Yusuke Shimizu, Yu Mimura, Shun Kudo, Satoyuki Ogino, Mimura Masaru

Asian Journal of Psychiatry, 68: 102966 (2022-02)

DOI
Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography

Vagenknecht, Patrick, Luzgin, Artur, Ono Maiko, Bin Ji, Higuchi Makoto, Noain, Daniela, Maschio, Cinzia A., Sobek, Jens, Chen, Zhenyue, Konietzko, Uwe; Gerez, Juan A, Riek, Roland, 他

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 49: 2137–2152 (2022-02)

DOI
D1- and D2-like receptors differentially mediate the effects of dopaminergic transmission on cost–benefit evaluation and motivation in monkeys

Yukiko Hori, Yuji Nagai, Koki Mimura, Tetsuya Suhara, Makoto Higuchi, Sebastien Bouret, Takafumi Minamimoto

PLOS Biology, 19(7): e3001055 (2022-01)

DOI
MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice

Takado Yuhei, Takuwa Hiroyuki, Kazuaki Sampei, Urushihata Takuya, Manami Takahashi, Shimojo Masafumi, Uchida Shoko, Nitta Nobuhiro, Shibata Sayaka, Nagashima Keisuke, Ochi Yoshihiro, Ono Maiko, Maeda Jun, Tomita Yutaka, Sahara Naruhiko, Jamie Near, Aoki Ichio, Shibata Kazuhisa, Higuchi Makoto

Journal of Cerebral Blood Flow & Metabolism, 42(1): 197–212 (2022-01)

DOI
Brain 5-HT2A receptor binding and its neural network related to behavioral inhibition system

Kojima Kazuho, Hirano Shigeki, Kimura Yasuyuki, Seki Chie, Ikoma Yoko, Takahata Keisuke, Ito Takehito, Yokokawa Keita, Hashimoto Hiroki, Kawamura Kazunori, Zhang Ming-Rong, Hiroshi Ito, Higuchi Makoto, Satoshi Kuwabara, Suhara Tetsuya, Yamada Makiko

Brain Imaging and Behavior, 16: 1337–1348 (2022-01)

DOI
First‐in‐human in vivo imaging and quantifcation of monoacylglycerol lipase in the brain: a PET study with 18F‐T‐401

Takahata Keisuke, Seki Chie, Kimura Yasuyuki, Kubota Manabu, Ichise Masanori, Sano Yasunori, Yasuharu Yamamoto, Tagai Kenji, Shimada Hitoshi, Kitamura Soichiro, Matsuoka Kiwamu, Endo Hironobu, Shinoto Hitoshi, Kawamura Kazunori, Zhang Ming-Rong, Takado Yuhei, Higuchi Makoto

European Journal of Nuclear Medicine and Molecular Imaging, 49: 3150–3161 (2022-01)

DOI
Adverse Childhood Experience Is Associated With Disrupted White Matter Integrity in Autism Spectrum Disorder: A Diffusion Tensor Imaging Study

Hiroaki Yoshikawa, Kitamura Soichiro, Matsuoka Kiwamu, Masato Takahashi, Rio Ishida, Naoko Kishimoto, Fumihiko Yasuno, Yuka Yasuda, Ryota Hashimoto, Toshiteru Miyasaka, Kimihiko Kichikawa, Toshifumi Kishimoto, Manabu Makinodan

Frontiers in Psychiatry, 12 (2022-01)

DOI

2021

Chemogenetic sensory fMRI reveals behaviorally relevant bidirectional changes in primate somatosensory network

Hirabayashi Toshiyuki, Nagai Yuji, Hori Yukiko, Ken-ichi Inoue, Aoki Ichio, Masahiko Takada, Suhara Tetsuya, Higuchi Makoto, Minamimoto Takafumi

Neuron, 109(20): 3312–3322.e1–e5 (2021-12)

DOI
Resting-state brain activity can predict target-independent aptitude in fMRI-neurofeedback training

Takashi Nakano, Masahiro Takamura, Haruki Nishimura, Maro Machizawa, Naho Ichikawa, Atsuo Yoshino, Go Okada, Yasumasa Okamoto, Shigeto Yamawaki, Makiko Yamada, Tetsuya Suhara, Junichiro Yoshimoto

NeuroImage, 245: 118733 (2021-12)

DOI
Dynamic alterations in the central glutamatergic status following food and glucose intake: in vivo multimodal assessments in humans and animal models

Kubota Manabu, Kimura Yasuyuki, Shimojo Masafumi, Takado Yuhei, Joao M.N. Duarte, Takuwa Hiroyuki, Seki Chie, Shimada Hitoshi, Shinoto Hitoshi, Takahata Keisuke, Kitamura Soichiro, Moriguchi Sho, Tagai Kenji, Obata Takayuki, Jin Nakahara, Tomita Yutaka, Tokunaga Masaki, Maeda Jun, Kawamura Kazunori, Zhang Ming-Rong, Ichise Masanori, Suhara Tetsuya, Higuchi Makoto

Journal of Cerebral Blood Flow & Metabolism, 41(11): 2928–2943 (2021-11)

DOI
A genetically targeted reporter for PET imaging of deep neuronal circuits in mammalian brains

Masafumi Shimojo, Maiko Ono, Hiroyuki Takuwa, Koki Mimura, Yuji Nagai, Masayuki Fujinaga, Tatsuya Kikuchi, Maki Okada, Chie Seki, Masaki Tokunaga, Jun Maeda, Yuhei Takado, Manami Takahashi, Takeharu Minamihisamatsu, Ming-Rong Zhang, Yutaka Tomita, Norihiro Suzuki, Anton Maximov, Tetsuya Suhara, Takafumi Minamimoto, Naruhiko Sahara, Makoto Higuchi

The EMBO Journal, 40(22): e107757 (2021-11)

DOI
Initial results of a mouse brain PET insert with a staggered 3-layer DOI detector

Hangyu Kang, Tashima Hideaki, Nishikido Fumihiko, Akamatsu Go, Wakizaka Hidekatsu, Higuchi Makoto, Yamaya Taiga

Physics in Medicine & Biology, 66(21): 210515 (2021-11)

DOI
Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy

Satoshi Muraoka, Annina M DeLeo, Zijian Yang, Tatebe Harutsugu, Kayo Yukawa-Takamatsu, Seiko Ikezu, Tokuda Takahiko, David Issadore, Robert A Stern, Tsuneya Ikezu

Aging and Disease, 12(6): 1363–1375 (2021-11)

DOI
Resting-state functional connectivity relates to interindividual variations in positive memory

Ayako Isato, Keita Yokokawa, Makoto Higuchi, Tetsuya Suhara, Makiko Yamada

Behavioural brain research, 419: 113663 (2021-11)

DOI
Excess tau PET ligand retention in elderly patients with major depressive disorder

Sho Moriguchi, Keisuke Takahata, Hitoshi Shimada, Manabu Kubota, Soichiro Kitamura, Yasuyuki Kimura, Kenji Tagai, Ryosuke Tarumi, Hajime Tabuchi, Jeffrey H. Meyer, Masaru Mimura, Kazunori Kawamura, Ming-Rong Zhang, Shigeo Murayama, Tetsuya Suhara, Makoto Higuchi

Molecular Psychiatry, 26: 5856–5863 (2021-11)

DOI
Pharmacokinetic and pharmacodynamic assessment of histamine H3 receptor occupancy by enerisant: a human PET study with a novel H3 binding ligand, [11C]TASP457

Yasuyuki Kimura, Keisuke Takahata, Toshiharu Shimazaki, Soichiro Kitamura, Chie Seki, Yoko Ikoma, Masanori Ichise, Kazunori Kawamura, Makiko Yamada, Ming-Rong Zhang, Makoto Higuchi, Izumi Nishino, Tetsuya Suhara

European journal of nuclear medicine and molecular imaging, 49: 1127–1135 (2021-10)

DOI
Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model

Hideaki Sato, Yuhei Takado, Sakiko Toyoda, Masako Tsukamoto-Yasui, Keiichiro Minatohara, Hiroyuki Takuwa, Takuya Urushihata, Manami Takahashi, Masafumi Shimojo, Maiko Ono, Jun Maeda, Asumi Orihara, Naruhiko Sahara, Ichio Aoki, Sachise Karakawa, Muneki Isokawa, Noriko Kawasaki, Mika Kawasaki, Satoko Ueno, Mayuka Kanda, Mai Nishimura, Katsuya Suzuki, Akira Mitsui, Kenji Nagao, Akihiko Kitamura, Makoto Higuchi

Science advances, 7(43): eabd5046 (2021-10)

DOI
Inhibition of transient receptor potential vanilloid type 1 through α2 adrenergic receptors at peripheral nerve terminals relieves pain

Yumi Matsushita, Miki Manabe, Issei Kitagawa, Masashi Higuchi, Yoshinao Z Hosaka, Naoki Kitamura

The Journal of veterinary medical science, 83(10): 1570–1581 (2021-10)

DOI
Exploring cell membrane water exchange in aquaporin-4-deficient ischemic mouse brain using diffusion-weighted MRI

Takuya Urushihata, Hiroyuki Takuwa, Manami Takahashi, Jeff Kershaw, Yasuhiko Tachibana, Nobuhiro Nitta, Sayaka Shibata, Masato Yasui, Makoto Higuchi, Takayuki Obata

European radiology experimental, 5(1): 44 (2021-10)

DOI
Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease

Satoshi Watanabe, Tohru Kurotani, Tomofumi Oga, Jun Noguchi, Risa Isoda, Akiko Nakagami, Kazuhisa Sakai, Keiko Nakagaki, Kayo Sumida, Kohei Hoshino, Koichi Saito, Izuru Miyawaki, Masayuki Sekiguchi, Keiji Wada, Minamimoto Takafumi, Ichinohe Noritaka

Nature Communications, 12: 5388 (2021-09)

DOI
Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder

Kitamura Soichiro, Manabu Makinodan, Matsuoka Kiwamu, Masato Takahashi, Hiroaki Yoshikawa, Rio Ishida, Naoko Kishimoto, Yasuno Fumihiko, Yuka Yasuda, Ryota Hashimoto, Toshiteru Miyasaka, Kimihiko Kichikawa, Toshifumi Kishimoto

Autism Research, 14(9): 1886–1895 (2021-09)

DOI
Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets

Mimura Koki, Nagai Yuji, Ken-ichi Inoue, Jumpei Matsumoto, Hori Yukiko, Sato Chika, Kei Kimura, Okauchi Takashi, Hirabayashi Toshiyuki, Hisao Nishijo, Yahata Noriaki, Masahiko Takada, Suhara Tetsuya, Higuchi Makoto, Minamimoto Takafumi

iScience, 24(9): 103066 (2021-08)

DOI
Detection of Alzheimer’s disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein

Bin Ji, Maiko Ono, Tomoteru Yamasaki, Masayuki Fujinaga, Ming-Rong Zhang, Chie Seki, Ichio Aoki, Seiji Kito, Makoto Sawada, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuchi

Journal of Cerebral Blood Flow and Metabolism, 41(8): 2076–2089 (2021-08)

DOI
A First-in-human Study of 11C-MTP38, a Novel PET Ligand for Phosphodiesterase 7

Kubota Manabu, Seki Chie, Kimura Yasuyuki, Takahata Keisuke, Shimada Hitoshi, Takado Yuhei, Matsuoka Kiwamu, Tagai Kenji, Sano Yasunori, Yasuharu Yamamoto, Okada Maki, Kikuchi Tatsuya, Ichise Masanori, Kawamura Kazunori, Zhang Ming-Rong, Higuchi Makoto

European Journal of Nuclear Medicine and Molecular Imaging, 48(9): 2846–2855 (2021-08)

DOI
Relationship between Regional Gray Matter Volumes and Dopamine D2 Receptor and Transporter in Living Human Brains

Kurose Shin, Kubota Manabu, Takahata Keisuke, Yasuharu Yamamoto, Fujiwara Hironobu, Kimura Yasuyuki, Hiroshi Ito, Hiroyoshi Takeuchi, Masaru Mimura, Suhara Tetsuya, Higuchi Makoto

Human Brain Mapping, 42(12): 4048–4058 (2021-07)

DOI
Single caudate neurons encode temporally discounted value for formulating motivation for action

Yukiko Hori, Koki Mimura, Yuji Nagai, Atsushi Fujimoto, Kei Oyama, Erika Kikuchi, Ken-Ichi Inoue, Masahiko Takada, Tetsuya Suhara, Barry J Richmond, Takafumi Minamimoto

eLife, 10: e61248 (2021-07)

DOI
Three-dimensional microvascular network reconstruction from in vivo images with adaptation of the regional inhomogeneity in the signal-to-noise ratio

Sugashi Takuma, Hiroya Yuki, Tomoya Niizawa, Takuwa Hiroyuki, Kanno Iwao, Masamoto Kazuto

Microcirculation, 28(5): e12697 (2021-07)

DOI
Pharmacological and genetic inhibition of translocator protein 18 kDa ameliorated neuroinflammation in murine endotoxemia model

Hiroshi Giga, Bin Ji, Kazuya Kikutani, Shuji Fukuda, Takashi Kitajima, Seishi Katsumata, Miho Matsumata, Tetsuya Suhara, Shigeto Yamawaki, Nobuaki Shime, Koji Hosokawa, Hidenori Aizawa

SHOCK, 56(1): 142–149 (2021-07)

DOI
Measurement of changes in endogenous serotonin level by positron emission tomography with [18F]altanserin

Yoko Ikoma, Hiroyuki Takuwa, Asuka Nishino, Jun Maeda, Kazunori Kawamura, Takayuki Obata, Ming-Rong Zhang, Makoto Higuchi, Tetsuya Suhara

Annals of Nuclear Medicine, 35: 955–965 (2021-06)

DOI
Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making

Oyama Kei, Hori Yukiko, Nagai Yuji, Miyakawa Naohisa, Mimura Koki, Hirabayashi Toshiyuki, Inoue Ken-ichi, Suhara Tetsuya, Masahiko Takada, Higuchi Makoto, Minamimoto Takafumi

Science Advances, 7(26): abg4246 (2021-06)

DOI
無意識の優越感が抑うつ症状に果たす役割

山田真希子, 伊里綾子

臨床精神医学, 50(5): 475–481 (2021-05)
[11C]deschloroclozapine is an improved PET radioligand for quantifying a human muscarinic DREADD expressed in monkey brain.

Xuefeng Yan, Sanjay Telu, Rachel M Dick, Jeih-San Liow, Paolo Zanotti-Fregonara, Cheryl L Morse, Lester S Manly, Robert L Gladding, Stal Shrestha, Walter Lerchner, Yuji Nagai, Takafumi Minamimoto, Sami S Zoghbi, Robert B Innis, Victor W Pike, Barry J Richmond, Mark Ag Eldridge

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 41(10): 2571–2581 (2021-05)

DOI
Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607

Yang Shi, Alexey G Murzin, Benjamin Falcon, Alexander Epstein, Jonathan Machin, Paul Tempest, Kathy L Newell, Ruben Vidal, Holly J Garringer, Naruhiko Sahara, Makoto Higuchi, Bernardino Ghetti, Ming-Kuei Jang, Sjors H W Scheres, Michel Goedert

Acta neuropathologica, 141: 697–708 (2021-05)

DOI
Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy.

Lauren H Fairley, Naruhiko Sahara, Ichio Aoki, Bin Ji, Tetsuya Suhara, Makoto Higuchi, Anna M Barron

Journal of neuroinflammation, 18(1): 76 (2021-05)

DOI
Differential pial and penetrating arterial responses examined by optogenetic activation of astrocytes and neurons

Nao Hatakeyama, Unekawa Miyuki, Juri Murata, Tomita Yutaka, Norihiro Suzuki, Jin Nakahara, Takuwa Hiroyuki, Kanno Iwao, Ko Matsu, Kenji F Tanaka, Masamoto Kazuto

Journal of Cerebral Blood Flow & Metabolism, 41(10): 2676–2689 (2021-04)

DOI
Synthesis and preclinical evaluation of [11C]MTP38 as a novel PET ligand for phosphodiesterase 7 in the brain

Obokata Naoyuki, Seki Chie, Takeshi Hirata, Maeda Jun, Ishii Hideki, Nagai Yuji, Matsuura Takahiro, Takakuwa Misae, Fukuda Hajime, Minamimoto Takafumi, Kawamura Kazunori, Zhang Ming-Rong, Nakajima Tatsuo, Saijo Takeaki, Higuchi Makoto

European Journal of Nuclear Medicine and Molecular Imaging, 48: 3101–3112 (2021-03)

DOI
PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey

Xiaoyun Zhou, Bin Ji, Chie Seki, Yuji Nagai, Takafumi Minamimoto, Masayuki Fujinaga, Ming-Rong Zhang, Takashi Saito, Takaomi C Saido, Tetsuya Suhara, Yasuyuki Kimura, Makoto Higuchi

Journal of cerebral blood flow and metabolism, 41(9): 2410–2422 (2021-03)

DOI
Design, Synthesis, and Biological Evaluation of Novel Fluorescent Probes Targeting the 18 kDa Translocator Protein

Hendris Wongso, Yamasaki Tomoteru, Kumata Katsushi, Ono Maiko, Higuchi Makoto, Zhang Ming-Rong, Michael Fulham, Andrew Katsifis, Paul Anthony Keller

ChemMedChem, 16(12): 1902–1916 (2021-02)

DOI
Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus

Madoka Nakajima, Shigeki Yamada, Masakazu Miyajima, Kazunari Ishii, Nagato Kuriyama, Hiroaki Kazui, Hideki Kanemoto, Takashi Suehiro, Kenji Yoshiyama, Masahiro Kameda, Yoshinaga Kajimoto, Mitsuhito Mase, Hisayuki Murai, Daisuke Kita, Teruo Kimura, Naoyuki Samejima, Takahiko Tokuda, Mitsunobu Kaijima, Chihiro Akiba, Kaito Kawamura, Masamichi Atsuchi, Yoshihumi Hirata, Mitsunori Matsumae, Makoto Sasaki, Fumio Yamashita, Shigeki Aoki, Ryusuke Irie, Hiroji Miyake, Takeo Kato, Etsuro Mori, Masatsune Ishikawa, Isao Date, Hajime Arai

Neurologia medico-chirurgica, 61(2): 63–97 (2021-02)

DOI
Artificial Optic Flow Guides Visual Attention in a Driving Scene.

Yoko Higuchi, Satoshi Inoue, Hiroto Hamada, Takatsune Kumada

Human factors, 62(4): 578–588 (2021-02)

DOI
Regulation of Anxiety and Depression by Mitochondrial Translocator Protein-Mediated Steroidogenesis: the Role of Neurons

Anna Barron, Makoto Higuchi, Satoko Hattori, Seiji Kito, Tetsuya Suhara, Bin Ji

Molecular Neurobiology, 58(2): 550–563 (2021-02)

DOI
Differential associations of dopamine synthesis capacity with the dopamine transporter and D2 receptor availability as assessed by PET in the living human brain

Yasuharu Yamamoto, Keisuke Takahata, Manabu Kubota, Harumasa Takano, Hiroyoshi Takeuchi, Yasuyuki Kimura, Yasunori Sano, Shin Kurose, Hiroshi Ito, Masaru Mimura, Makoto Higuchi

NeuroImage, 226: 117543 (2021-02)

DOI
A case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex presenting as progressive parkinsonism with corresponding tau imaging

Yasuyuki Ohta, Hitoshi Shimada, Ken Ikegami, Keiichiro Tsunoda, Nozomi Hishikawa, Mami Takemoto, Yoshio Omote, Kenji Tagai, Kiwamu Matsuoka, Makoto Higuchi, Koji Abe

Neurology and Clinical Neuroscience, 9(1): 124–126 (2021-01)

DOI
High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

Kenji Tagai, Maiko Ono, Manabu Kubota, Soichiro Kitamura, Keisuke Takahata, Chie Seki, Yuhei Takado, Hitoshi Shinoto, Yasunori Sano, Yasuharu Yamamoto, Kiwamu Matsuoka, Hiroyuki Takuwa, Masafumi Shimojo, Manami Takahashi, Kazunori Kawamura, Tatsuya Kikuchi, Maki Okada, Haruhiko Akiyama, Hisaomi Suzuki, Mitsumoto Onaya, Takahiro Takeda, Kimihito Arai, Nobutaka Arai, Nobuyuki Araki, Yuko Saito, John Q. Trojanowski, Virginia M.Y. Lee, Sushil K. Mishra, Yoshiki Yamaguchi, Yasuyuki Kimura, Masanori Ichise, Yutaka Tomita, Ming-Rong Zhang, Tetsuya Suhara, Masahiro Shigeta, Naruhiko Sahara, Makoto Higuchi, Hitoshi Shimada

Neuron, 109(1): 42–5800000000 (2021-01)

DOI
Pick’s Tau Fibril Shows Multiple Distinct PET Probe Binding Sites: Insights from Computational Modelling

Sushil K. Mishra, Yoshiki Yamaguchi, Makoto Higuchi, Naruhiko Sahara

International Journal of Molecular Sciences, 22(1): 349 (2021-01)

DOI
Distinct microglial response against Alzheimer’s amyloid and tau pathologies characterized by P2Y12 receptor

Jun Maeda, Takeharu Minamihisamatsu, Masafumi Shimojo, Zhou Xiaoyun, Maiko Ono, Yukio Matsuba, Bin Ji, Hideki Ishii, Masanao Ogawa, Hiroyasu Akatsu, Daita Kaneda, Yoshio Hashizume, John L. Robinson, Virginia M-Y Lee, Takashi Saito, Takaomi C. Saido, John Q. Trojanowski, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi, Naruhiko Sahara

Brain Communications, 3(1): fcab011 (2021-01)

DOI
Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease

Akira Sobue, Okiru Komine, Yuichiro Hara, Fumito Endo, Hiroyuki Mizoguchi, Seiji Watanabe, Shigeo Murayama, Takashi Saito, Takaomi C. Saido, Naruhiko Sahara, Makoto Higuchi, Tomoo Ogi, Koji Yamanaka

Acta Neuropathologica Communications, 9(1): 1 (2021-01)

DOI
In vivo multimodal imaging of adenosine A1 receptors in neuroinflammation after experimental stroke

Ana Joya, María Ardaya, Alejandro Montilla, Maider Garbizu, Sandra Plaza-García, Vanessa Gómez-Vallejo, Daniel Padro, Juan José Gutiérrez, Xabier Rios, Pedro Ramos-Cabrer, Unai Cossío, Krishna R Pulagam, Makoto Higuchi, María Domercq, Fabio Cavalier, Carlos Matute, Jordi Llop, Abraham Martín

Theranostics, 11(1): 410–425 (2021-01)

DOI
Biodistribution and radiation dosimetry of the positron emission tomography probe for AMPA receptor, [11C]K-2, in healthy human subjects

Mai Hatano, Tomoyuki Miyazaki, Yoshinobu Ishiwata, Waki Nakajima, Tetsu Arisawa, Yoko Kuroki, Ayako Kobayashi, Yuuki Takada, Matsuyoshi Ogawa, Kawamura Kazunori, Ming‐Rong Zhang, Makoto Higuchi, MasatakaTaguri, Yasuyuki Kimura, Takuya Takahashi

Scientific Reports, 11(1): 1598 (2021-01)

DOI

2020

Impact of past experiences on decision-making in autism spectrum disorder.

Junya Fujino, Shisei Tei, Takashi Itahashi, Yuta Y. Aoki, Haruhisa Ohta, Manabu Kubota, Ryu-Ichiro Hashimoto, Motoaki Nakamura, Nobumasa Kato, Hidehiko Takahashi

European archives of psychiatry and clinical neuroscience, 270(8): 1063–1071 (2020-12)

DOI
Spatial variability induces generalization in contextual cueing.

Yoko Higuchi, Yoshiyuki Ueda, Kazuhisa Shibata, Jun Saiki

Journal of experimental psychology. Learning, memory, and cognition, 46(12): 2295–2313 (2020-12)

DOI
Identification and in vitro characterization of C05-01, a PPB3 derivative with improved affinity for alpha-synuclein

Patricia Miranda-Azpiazu, Marie Svedberg, Makoto Higuchi, Maiko Ono, Zhisheng Jia, Dan Sunnemark, Charles S.Elmore, Magnus Schou, Andrea Varrone

Brain Research, 1749: 147131 (2020-12)

DOI
Quantification of Blood Caffeine Levels in Patients With Parkinson's Disease and Multiple System Atrophy by Caffeine ELISA

Takuma Ohmichi, Takashi Kasai, Makiko Shinomoto, Jun Matsuura, Takashi Koizumi, Fukiko Kitani-Morii, Harutsugu Tatebe, Hidenao Sasaki, Toshiki Mizuno, Takahiko Tokuda

frontiers in Neurology, 11: 580127 (2020-12)

DOI
The Neuropsychological Correlates of Brain Perfusion and Gray Matter Volume in Alzheimer’s Disease

Tai Hong, Hirano Shigeki, Sakurai Toru, Nakano Yoshikazu, Ishikawa Ai, Kojima Kazuho, Li Hongliang, Shimada Hitoshi, Kashiwado Koichi, Mukai Hiroki, Horikoshi Takuro, Sugiyama Atsuhiko, Uno Takashi, Kuwabara Satoshi

Journal of Alzheimer's Disease, 78(4): 1639–1652 (2020-12)

DOI
Binding of dopamine D1 receptor and noradrenaline transporter in individuals with autism spectrum disorder: A PET study

Manabu Kubota, Junya Fujino, Shisei Tei, Keisuke Takahata, Kiwamu Matsuoka, Kenji Tagai, Yasunori Sano, Yasuharu Yamamoto, Hitoshi Shimada, Yuhei Takado, Chie Seki, Takashi Itahashi, Yuta Y. Aoki, Haruhisa Ohta, Ryu-ichiro Hashimoto, Ming-Rong Zhang, Tetsuya Suhara, Motoaki Nakamura, Hidehiko Takahashi, Nobumasa Kato, Makoto Higuchi

Cerebral Cortex, 30(12): 6458–6468 (2020-11)

DOI
Radiosynthesis and quality control testing of the tau imaging positron emission tomography tracer [18F]PM‐PBB3 for clinical applications

Kazunori Kawamura, Hiroki Hashimoto, Kenji Furutsuka, Takayuki Ohkubo, Tomoya Fujishiro, Takahiro Togashi, Daisuke Arashi, Toshiyuki Sakai, Masatoshi Muto, Masanao Ogawa, Yusuke Kurihara, Nobuki Nengaki, Makoto Takei, Kazuyoshi Nemoto, Makoto Higuchi, Ming-Rong Zhang

Journal of Labelled Compounds and Radiopharmaceuticals, 64(3): 109–119 (2020-11)

DOI
Development of a multi-use human-scale single-ring OpenPET system

Hideaki Tashima, Eiji Yoshida, Yuma Iwao, Hidekatsu Wakizaka, Akram Mohammadi, Munetaka Nitta, Atsushi Kitagawa, Taku Inaniwa, Fumihiko Nishikido, Atsushi Tsuji, Yuji Nagai, Chie Seki, Takafumi Minamimoto, Yasuhisa Fujibayashi, Taiga Yamaya

IEEE Transactions on Radiation and Plasma Medical Sciences, 61(4): 1795 (2020-11)

DOI
In vivo PET imaging of mitochondrial abnormalities in a mouse model of tauopathy

Anna Barron, Bin Ji, MasayukiFujinaga, Ming-Rong Zhang, Naruhiko Sahara, Ichio Aoki, Hideo Tsukada, Makoto Higuchi

Neurobiology of Aging, 94: 140–148 (2020-10)

DOI
Increased Dendritic Orientation Dispersion in the Left Occipital Gyrus is Associated with Atypical Visual Processing in Adults with Autism Spectrum Disorder

Kiwamu Matsuoka, Manabu Makinodan, Soichiro Kitamura, Masato Takahashi, Hiroaki Yoshikawa, Fumihiko Yasuno, Rio Ishida, Naoko Kishimoto, Yuka Yasuda, Ryota Hashimoto, Toshiaki Taoka, Toshiteru Miyasaka, Kimihiko Kichikawa, Toshifumi Kishimoto

Cerebral Cortex, 30(11): 5617–5625 (2020-10)

DOI
The Imaging Features and Clinical Associations of a Novel Tau PET Tracer—18F-APN1607 in Alzheimer Disease

Hsu Jung-Lung, Lin Kun-Ju, Hsiao Ing-Tsung, Huang Kuo-Lun, Liu Chi-Hung, Wu Hsiu-Chuan, Weng Yi-Ching, Huang Chu-Yun, Chang Chiung-Chih, Yen Tzu-Chen, Makoto Higuchi, Jang Ming-Kuei, Huang Chin-Chang

CLINICAL NUCLEAR MEDICINE, 45(10): 747–756 (2020-10)

DOI
Novel Drosophila model for parkinsonism by targeting phosphoglycerate kinase

Joe Shimizu, Takashi Kasai, Hideki Yoshida, Anh M. Huynh, Yumiko Nakao-Azuma, Makiko Shinomoto, Takahiko Tokuda, Toshiki Mizuno, Masamitsu Yamaguchi

Neurochemistry International, 139: 104816 (2020-10)

DOI
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys

Yuji Nagai, Naohisa Miyakawa, Hiroyuki Takuwa, Yukiko Hori, Kei Oyama, Bin Ji, Takahashi Manami, Xi-Ping Huang, Samuel T. Slocum, Jeffrey F. DiBerto, Yan Xiong, Takuya Urushihata, Toshiyuki Hirabayashi, Atsushi Fujimoto, Koki Mimura, Justin G. English, Jing Liu, Ken-ichi Inoue, Katsushi Kumata, Chie Seki, Maiko Ono, Masafumi Shimojo, Ming-Rong Zhang, Yutaka Tomita, Jin Nakahara, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Jian Jin, Bryan L. Roth, Takafumi Minamimoto

Nature Neuroscience, 23(9): 1157–1167 (2020-09)

DOI
Progressive Parkinsonism Three Years after Shunt Surgery in a Patient with Idiopathic Normal Pressure Hydrocephalus

Hitoshi Shimada, Yasuo Shimada

Internal Medicine, 59(17): 2183–2186 (2020-09)

DOI
Treatment effects on neurometabolite levels in schizophrenia: A systematic review and meta-analysis of proton magnetic resonance spectroscopy studies.

Manabu Kubota, Sho Moriguchi, Keisuke Takahata, Shinichiro Nakajima, Nobuyuki Horita

Schizophrenia research, 222: 122–132 (2020-08)

DOI
視覚的オブジェクトの「機能」による認識

太田直斗, 相澤裕紀, 厳島行雄

認知心理学研究, 18(1): 13–24 (2020-08)

DOI
Protein Deficiency-Induced Behavioral Abnormalities and Neurotransmitter Loss in Aged Mice Are Ameliorated by Essential Amino Acids

Hideaki Sato, Masako Tsukamoto-Yasui, Yuhei Takado, Noriko Kawasaki, Keiko Matsunaga, Satoko Ueno, Mayuka Kanda, Mai Nishimura, Sachise Karakawa, Muneki Isokawa, Katsuya Suzuki, Kenji Nagao, Makoto Higuchi, Akihiko Kitamura

Frontiers in Nutrition, 7: 23–1 (2020-06)

DOI
Treatment effects on neurometabolite levels in schizophrenia: A meta-analysis dataset of proton magnetic resonance spectroscopy

Manabu Kubota, Sho Moriguchi, Keisuke Takahata, Shinichiro Nakajima, Nobuyuki Horita

Data in Brief, 31: 105862 (2020-06)

DOI
Heavy Tau Burden with Subtle Amyloid β Accumulation in the Cerebral Cortex and Cerebellum in a Case of Familial Alzheimer’s Disease with APP Osaka Mutation

Hiroyuki Shimada, Shinobu Minatani, Jun Takeuchi, Akitoshi Takeda, Joji Kawabe, Yasuhiro Wada, Aya Mawatari, Yasuyoshi Watanabe, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Takami Tomiyama, Yoshiaki Itoh

International Journal of Molecular Sciences, 21(12): 4443 (2020-06)

DOI
Biological washout modelling for in-beam PET: rabbit brain

Chie Toramatsu, Akram Mohammadi, Hidekatsu Wakizaka, Chie Seki, Fumihiko Nishikido, Shinji Sato, Miwako Takahashi, Kumiko Karasawa, Yoshiyuki Hirano, Taiga Yamaya

Physics in Medicine & Biology, 65(10): 105011-1–105011-12 (2020-05)

DOI
CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers

Nour K Majbour, Jan O Aasly, Eldbjørg Hustad, Mercy A Thomas, Nishant N Vaikath, Naser Elkum, Wilma D J van de Berg, Takahiko Tokuda, Brit Mollenhauer, Henk W. Berendse, Omar M. A. El-Agnaf

Translational Neurodegeneration, 9(1): 15 (2020-05)

DOI
Role of the right temporoparietal junction in intergroup bias in trust decisions

Junya Fujino, Shisei Tei, Takashi Itahashi, Yuta Y. Aoki, Haruhisa Ohta, Manabu Kubota, Ryu-ichiro Hashimoto, Hidehiko Takahashi, Nobumasa Kato, Motoaki Nakamura

Human Brain Mapping, 41(6): 1677–1688 (2020-04)

DOI
Selective disruption of inhibitory synapses leading to neuronal hyperexcitability at an early stage of tau pathogenesis in a mouse model.

Masafumi Shimojo, Hiroyuki Takuwa, Yuhei Takado, Masaki Tokunaga, Satoshi Tsukamoto, Keiichiro Minatohara, Maiko Ono, Chie Seki, Jun Maeda, Takuya Urushihata, Takeharu Minamihisamatsu, Ichio Aoki, Kazunori Kawamura, Ming-Rong Zhang, Tetsuya Suhara, Naruhiko Sahara, Makoto Higuchi

Journal of Neuroscience, 40(17): 3491–3501 (2020-04)

DOI
Overlapping but Asymmetrical Relationships Between Schizophrenia and Autism Revealed by Brain Connectivity.

Yujiro Yoshihara, Giuseppe Lisi, Noriaki Yahata, Junya Fujino, Yukiko Matsumoto, Jun Miyata, Gen-Ichi Sugihara, Shin-Ichi Urayama, Manabu Kubota, Masahiro Yamashita, Ryuichiro Hashimoto, Naho Ichikawa, Weipke Cahn, Neeltje E M van Haren, Susumu Mori, Yasumasa Okamoto, Kiyoto Kasai, Nobumasa Kato, Hiroshi Imamizu, René S Kahn, Akira Sawa, Mitsuo Kawato, Toshiya Murai, Jun Morimoto, Hidehiko Takahashi

Schizophrenia bulletin, 46(5): 1210–1218 (2020-04)

DOI
Relationship between person with dementia and adolescents: A preliminary survey of the Association Between Children and Dementia Elders (ABCDE) Project

Shigeki Hirano, Keisuke Shimizu, Noriko Murayama, Moeno Ishikawa, Shogo Furukawa, Kazuho Kojima, Ai Ishikawa, Hitoshi Shimada, Hitoshi Shinoto, Koichi Kashiwado, Tsuyoshi Sasaki, Masaomi Iyo, Satoshi Kuwabara

Nursing Palliative Care, 5: 1–6 (2020-04)

DOI
Staging of tau distribution by positron emission tomography may be useful in clinical staging of Alzheimer disease

Kenta Aohara, Shinobu Minatani, Hiroko Kimura, Jun Takeuchi, Akitoshi Takeda, Joji Kawabe, Yasuhiro Wada, Aya Mawatari, Yasuyoshi Watanabe, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Yoshiaki Itoh

Neurology and Clinical Neuroscience, 8(2): 61–67 (2020-03)

DOI
Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice

Hiroki Takeuchi, Keiko Imamura, Bin Ji, Kayoko Tsukita, Takako Enami, Keizo Takao, Tsuyoshi Miyakawa, Masato Hasegawa, Naruhiko Sahara, Nobuhisa Iwata, Makoto Inoue, Hideo Hara, Takeshi Tabira, Maiko Ono, John Trojanowski, Virginia Lee, Ryosuke Takahashi, Tetsuya Suhara, Makoto Higuchi, Haruhisa Inoue

npj Vaccines, 5(28) (2020-03)

DOI
Macaques exhibit implicit gaze bias anticipating others’ false belief-driven actions via the medial prefrontal cortex

Taketsugu Hayashi, Ryota Akikawa, Keisuke Kawasaki, Jun Egawa, Takafumi Minamimoto, Kazuto Kobayashi, Shigeki Kato, Yukiko Hori, Yuji Nagai, Atsuhiko Iijima, Toshiyuki Someya, Isao Hasegawa

Cell Reports, 30(13): 4433–4444 (2020-03)

DOI
Accelerating the evolution of nonhuman primate neuroimaging

Michael Milham, Christopher I. Petkov, Tomoko Sakai, others

Neuron, 105(4): 600–603 (2020-02)

DOI
Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants.

Naho Ichikawa, Giuseppe Lisi, Noriaki Yahata, Go Okada, Masahiro Takamura, Ryu-Ichiro Hashimoto, Takashi Yamada, Makiko Yamada, Tetsuya Suhara, Sho Moriguchi, Masaru Mimura, Yujiro Yoshihara, Hidehiko Takahashi, Kiyoto Kasai, Nobumasa Kato, Shigeto Yamawaki, Ben Seymour, Mitsuo Kawato, Jun Morimoto, Yasumasa Okamoto

Scientific reports, 10(1): 3542 (2020-02)

DOI
Visualization of AMPA receptors in living human brain with positron emission tomography

Tomoyuki Miyazaki, Waki Nakajima, Mai Hatano, Yusuke Shibata, Yoko Kuroki, Tetsu Arisawa, Asami Serizawa, Akane Sano, Sayaka Kogami, Tomomi Yamanoue, Kimito Kimura, Yushi Hirata, Yuuki Takada, Yoshinobu Ishiwata, Masaki Sonoda, Masaki Tokunaga, Chie Seki, Yuji Nagai, Takafumi Minamimoto, Kazunori Kawamura, Ming-Rong Zhang, Naoki Ikegaya, Masaki Iwasaki, Naoto Kunii, Yuichi Kimura, Fumio Yamashita, Masataka Taguri, Hidaaki Tani, Nobuhiro Nagai, Teruki Koizumi, Shinichiro Nakajima, Masaru Mimura, Michisuke Yuzaki, Hiroki Kato, Makoto Higuchi, Hiroyuki Uchida, Takuya Takahashi

Nature Medicine, 26(2): 281–288 (2020-02)

DOI
In vivo monitoring of remnant undifferentiated neural cells following human iPS cell‐derived neural stem/progenitor cells transplantation

Yuji Tanimoto, Tomoteru Yamasaki, Narihito Nagoshi, Yuichiro Nishiyama, Satoshi Nori, Soraya Nishimura, Tsuyoshi Iida, Masahiro Ozaki, Osahiko Tsuji, Bin Ji, Ichio Aoki, Masahiro Jinzaki, Morio Matsumoto, Yasuhisa Fujibayashi, Ming-Rong Zhang, Masaya Nakamura, Hideyuki Okano

STEM CELLS TRANSLATIONAL MEDICINE, 9(4): 465–477 (2020-01)

DOI
Diagnostic Value of Muscle [11C] PIB-PET in Inclusion Body Myositis

Yu-ichi Noto, Masaki Kondo, Yukiko Tsuji, Shigenori Matsushima, Toshiki Mizuno, Takahiko Tokuda, Masanori Nakagawa

Frontiers in Neurology, 10: 1386 (2020-01)

DOI

2019

Egocentric biases and atypical generosity in autistic individuals.

Shisei Tei, Junya Fujino, Takashi Itahashi, Yuta Aoki, Haruhisa Ohta, Manabu Kubota, Ryu-Ichiro Hashimoto, Motoaki Nakamura, Nobumasa Kato, Hidehiko Takahashi

Autism research, 12(11): 1598–1608 (2019-11)

DOI
Pain matrix shift in the rat brain following persistent colonic inflammation revealed by voxel-based statistical analysis.

Tianliang Huang, Takashi Okauchi, Di Hu, Mika Shigeta, Yuping Wu, Yasuhiro Wada, Emi Hayashinaka, Shenglan Wang, Yoko Kogure, Koichi Noguchi, Yasuyoshi Watanabe, Yi Dai, Yilong Cui

Molecular pain, 15: 1744806919891327 (2019-11)

DOI
Task-irrelevant optic flow guides attention in visual search.

Yoko Higuchi, Satoshi Inoue, Terumasa Endo, Takatsune Kumada

Attention, perception & psychophysics, 81(5): 1327–1345 (2019-11)

DOI
PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury

Keisuke Takahata, Yasuyuki Kimura, Naruhiko Sahara, Shunsuke Koga, Hitoshi Shimada, Masanori Ichise, Fumie Saito, Sho Moriguchi, Soichiro Kitamura, Manabu Kubota, Satoshi Umeda, Fumitoshi Niwa, Jin Mizushima, Yoko Morimoto, Ming-Rong Zhang, Dennis W. Dickson, Masaru Mimura, Motoichiro Kato, Tetsuya Suhara, Makoto Higuchi

BRAIN, 142(10): 3265–3279 (2019-10)

DOI
Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs

Mari Nakamura, Seiji Shiozawa, Daisuke Tsuboi, Mutsuki Amano, Hirotaka Watanabe, Sumihiro Maeda, Taeko Kimura, Sho Yoshimatsu, Fumihiko Kisa, Celeste M. Karch, Tomohiro Miyasaka, Akihiko Takashima, Naruhiko Sahara, Shin-ichi Hisanaga, Takeshi Ikeuchi, Kozo Kaibuchi, Hideyuki Okano

Stem Cell Reports, 13(4): 684–699 (2019-10)

DOI
Computer-assisted cognitive remediation therapy for patients with schizophrenia induces microstructural changes in cerebellar regions involved in cognitive functions.

Kiwamu Matsuoka, Tsubasa Morimoto, Yasuhiro Matsuda, Fumihiko Yasuno, Toshiaki Taoka, Toshiteru Miyasaka, Hiroaki Yoshikawa, Masato Takahashi, Soichiro Kitamura, Kimihiko Kichikawa, Toshifumi Kishimoto

Psychiatry Research: Neuroimaging, 292: 41–46 (2019-10)

DOI
Depth inversion with a 3D structure influences brightness perception.

Tetsuya Arai, Tomohiro Masuda, Yuka Igarashi, Keiko Omori, Yasunori Aizawa, Naoe Masuda

PloS one, 14(10): e0224192 (2019-10)

DOI
Transclival clipping for giant vertebral artery aneurysm: A case report

Tsubasa Okuyama, Yoshinori Higuchi, Tatsuma Matsuda, Akihiko Adachi, Eiichi Kobayashi, Yasuo Iwadate, Kentaro Horiguchi

Interdisciplinary Neurosurgery, 17: 107–112 (2019-09)

DOI
Differentiation Between Dementia With Lewy Bodies And Alzheimer’s Disease Using Voxel-Based Morphometry Of Structural MRI:AMulticenter Study

Hiroshi Matsuda, Kota Yokoyama, Noriko Sato, Kengo Ito, Kiyotaka Nemoto, Hiroshi Oba, Haruo Hanyu, Hidekazu Kanetaka, Sunao Mizumura, Shin Kitamura, Hitoshi Shinotoh, Hitoshi Shimada, Tetsuya Suhara, Hitoshi Terada, Tomoya Nakatsuka, Shinobu Kawakatsu, Hiroshi Hayashi, Takashi Asada, Tetsutaro Ono, Tomoaki Goto, Keiko Shigemori

Neuropsychiatric Disease and Treatment, 15: 2715–2722 (2019-09)

DOI
Classification of Clinically Diagnosed Alzheimer's Disease Associated with Diabetes Based on Amyloid and Tau PET Results

Takenoshita, Naoto, Shimizu, Soichiro, Kanetaka, Hidekazu, Sakurai, Hirofumi, Suzuki, Ryo, Miwa, Takashi, Odawara, Masato, Ishii, Kenji, Hitoshi Shimada, Higuchi, Makoto, Tetsuya Suhara, Hanyu, Haruo

Journal of Alzheimer's Disease, 71(1): 261–271 (2019-09)

DOI
Trait and State-Dependent Risk Attitude of Monkeys Measured in a Single-Option Response Task

Atsushi Fujimoto, Takafumi Minamimoto

Frontiers in neuroscience, 13: 816 (2019-08)

DOI
Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation

Takashi Saito, Naomi Mihira, Yukio Matsuba, Hiroki Sasaguri, Shoko Hashimoto, Sneha Narasimhan, Bin Zhang, Shigeo Murayama, Makoto Higuchi, Virginia M. Y. Lee, John Q. Trojanowski, Takaomi C. Saido

The Journal of Biological Chemistry, 294(34): 12754–12765 (2019-08)

DOI
Abnormal axon guidance signals and reduced interhemispheric connection via anterior commissure in neonates of marmoset ASD model.

Koki Mimura, Tomofumi Oga, Tetsuya Sasaki, Keiko Nakagaki, Chika Sato, Kayo Sumida, Kohei Hoshino, Koichi Saito, Izuru Miyawaki, Tetsuya Suhara, Ichio Aoki, Takafumi Minamimoto, Noritaka Ichinohe

NeuroImage, 195: 243–251 (2019-07)

DOI
Tau isoform expression and phosphorylation in marmoset brains

Sharma Govind, Huo Anni, Taeko Kimura, Shiozawa Seiji, Kobayashi Reona, Naruhiko Sahara, Ishibashi Minaka, Ishigaki Shinsuke, Saito Taro, Ando Kanae, Murayama Shigeo, Hasegawa Masato, Sobue Gen, Okano Hideyuki, Hisanaga Shin-ichi

Journal of Biological Chemistry, 294(30): 11433–11444 (2019-07)

DOI
Association between Brain and Plasma Glutamine Levels in Healthy Young Subjects Investigated by MRS and LC/MS.

Yuhei Takado, Naoto Sato, Yuta Kanbe, Moyoko Tomiyasu, Lijing Xin, Jamie Near, Kohki Yoshikawa, Naruhiko Sahara, Tatsuya Higashi, Tetsuya Suhara, Makoto Higuchi, Takayuki Obata

Nutrients, 11(7): 1649 (2019-07)

DOI
Segmented Iba1-Positive Processes of Microglia in Autism Model Marmosets

Tomomi Sanagi, Tetsuya Sasaki, Keiko Nakagaki, Takafumi Minamimoto, Shinichi Kohsaka, Noritaka Ichinohe

Frontiers in cellular neuroscience, 13: 344 (2019-07)

DOI
Associations between self-reported impulsivity and a latent variable of impulsive action constructed from three laboratory tasks

Akira Hasegawa, Keita Somatori, Haruki Nishimura, Yusuke Hattori, Kunisato Yoshihiko

Journal of Experimental Psychopathology, 10(3) (2019-07)

DOI
Tau binding protein CAPON induces tau aggregation and neurodegeneration

Shoko Hashimoto, Yukio Matsuba, Naoko Kamano, Naomi MIhira, Naruhiko Sahara, Jiro Takano, Shin-ichi Muramatsu, Takaomi C. Saido, Takashi Saito

Nature Communications, 10(1): 2394 (2019-06)

DOI
The Utility of Applying Various Image Preprocessing Strategies to reduce the ambiguity in Deep Learning-Based Clinical Image Diagnosis

Yasuhiko Tachibana, Takayuki Obata, Jeffrey Kershaw, Hironao Sakaki, Takuya Urushihata, Tokuhiko Omatsu, Riwa Kishimoto, Tatsuya Higashi

Magnetic Resonance in Medical Sciences, 19(2): 92–98 (2019-05)

DOI
In vivo direct relation of tau pathology with neuroinflammation in early Alzheimer's disease.

Tatsuhiro Terada, Masamichi Yokokura, Tomokazu Obi, Tomoyasu Bunai, Etsuji Yoshikawa, Ichiro Ando, Hitoshi Shimada, Tetsuya Suhara, Makoto Higuchi, Yasuomi Ouchi

Journal of neurology, 266(9): 2186–2196 (2019-05)

DOI
In Vivo Binding of a Tau Imaging Probe, [11C]PBB3, in Patients With Progressive Supranuclear Palsy

Hironobu Endo, Hitoshi Shimada, Naruhiko Sahara, Maiko Ono, Shunsuke Koga, Soichiro Kitamura, Fumitoshi Niwa, Shigeki Hirano, Yasuyuki Kimura, Masanori Ichise, Hitoshi Shinotoh, Ming Rong Zhang, Satoshi Kuwabara, Dennis W. Dickson, Tatsushi Toda, Tetsuya Suhara, Makoto Higuchi

Movement Disorders, 34(5): 744–754 (2019-05)

DOI
Neural signals in amygdala predict implicit prejudice toward an ethnic outgroup.

Keise Izuma, Ryuta Aoki, Kazuhisa Shibata, Kiyoshi Nakahara

NeuroImage, 189: 341–352 (2019-04)

DOI
Clinical Heterogeneity of Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 Caused by MAPT N279K Mutation in Relation to Tau Positron Emission Tomography Features

Aya Ikeda, Hitoshi Shimada, Kenya Nishioka, Masashi Takanashi, Arisa Hayashida, Yuanzhe Li, Hiroyo Yoshino, Manabu Funayama, Yuji Ueno, Taku Hatano, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi, Nobutaka Hattori

Movement Disorders, 34(4): 568–574 (2019-04)

DOI
Amyloid-Negative Dementia in the Elderly is Associated with High Accumulation of Tau in the Temporal Lobes

Jun Takeuchi, Takayuki Kikukawa, Haruna Saito, Itsuki Hasegawa, Akitoshi Takeda, Hiroyuki Hatsuta, Joji Kawabe, Yasuhiro Wada, Aya Mawatari, Ami Igesaka, Hisashi Doi, Yasuyoshi Watanabe, Hitoshi Shimada, Soichiro Kitamura, Makoto Higuchi, Tetsuya Suhara, Yoshiaki Itoh

The Open Biomedical Engineering Journal, 13: 55–66 (2019-03)

DOI
Design, Synthesis, and Evaluation of (4 R)-1-{3-[2-(F)Fluoro-4-methylpyridin-3-yl]phenyl}-4-[4-(1,3-thiazol-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one ([F]T-401) as a Novel Positron-Emission Tomography Imaging Agent for Monoacylglycerol Lipase.

Yasushi Hattori, Kazunobu Aoyama, Jun Maeda, Naoto Arimura, Yasuko Takahashi, Masako Sasaki, Masayuki Fujinaga, Chie Seki, Yuji Nagai, Kazunori Kawamura, Tomoteru Yamasaki, Ming-Rong Zhang, Makoto Higuchi, Tatsuki Koike

Journal of medicinal chemistry, 62(5): 2362–2375 (2019-03)

DOI
Voxel-Based Acetylcholinesterase PET Study in Early and Late Onset Alzheimer's Disease.

Shigeki Hirano, Hitoshi Shinoto, Hitoshi Shimada, Tsuneyoshi Ota, Koichi Sato, Noriko Tanaka, Ming-Rong Zhang, Makoto Higuchi, Kiyoshi Fukushi, Toshiaki Irie, Satoshi Kuwabara, Tetsuya Suhara

Journal of Alzheimer’s Disease, 62(4): 1539–1548 (2019-03)

DOI
Signaling Incentive and Drive in the Primate Ventral Pallidum for Motivational Control of Goal-Directed Action

Atsushi Fujimoto, Yukiko Hori, Yuji Nagai, Erika Kikuchi, Kei Oyama, Tetsuya Suhara, Takafumi Minamimoto

Journal of Neuroscience, 39(10): 1793–1804 (2019-03)

DOI
Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity.

Masafumi Shimojo, Joseph Madara, Sandra Pankow, Xinran Liu, John Yates III, Thomas C Südhof, Anton Maximov

Genes & development, 33(5-6): 365–376 (2019-03)

DOI
Toward a comprehensive understanding of the neural mechanisms of decoded neurofeedback.

Kazuhisa Shibata, Giuseppe Lisi, Aurelio Cortese, Takeo Watanabe, Yuka Sasaki, Mitsuo Kawato

NeuroImage, 188: 539–556 (2019-03)

DOI
First prototyping of a dedicated PET system with the hemisphere detector arrangement

Hideaki Tashima, Eiji Yoshida, Yuma Iwao, Hidekatsu Wakizaka, Takamasa Maeda, Chie Seki, Yasuyuki Kimura, Yuhei Takado, Makoto Higuchi, Tetsuya Suhara, Taichi Yamashita, Taiga Yamaya

Physics in Medicine and Biology, 64(6): 065004 (2019-03)

DOI
Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia

Yifei Lu, Zhongyuan Guo, Yujie Zhang, Chao Hui Li, Yu Zhang, Qin Guo, Qinjun Chen, Xinli Chen, Xi He, Lisha Liu, Chunhui Ruan, Tao Sun, Bin Ji, Bin Ji, Weigen Lu, Chen Jiang

Advanced Science, 6(4): 1801586 (2019-02)

DOI
Cerebral serotonin transporter measurements with [11C]DASB: A review on acquisition and preprocessing across 21 PET centres.

Martin Nørgaard, Melanie Ganz, Claus Svarer, Ling Feng, Masanori Ichise, Rupert Lanzenberger, Mark Lubberink, Ramin V Parsey, Marios Politis, Eugenii A Rabiner, Mark Slifstein, Vesna Sossi, Tetsuya Suhara, Peter S Talbot, Federico Turkheimer, Stephen C Strother, Gitte M Knudsen

Journal of Cerebral Blood Flow & Metabolism, 39(2): 210–222 (2019-02)

DOI
Recruitment of calbindin into nigral dopamine neurons protects against MPTP-Induced parkinsonism.

Ken-ichi Inoue, Shigehiro Miyachi, Katsunori Nishi, Haruo Okado, Yuji Nagai, Takafumi Mainamimoto, Atsushi Nambu, Masahiko Takada

Movement Disorders, 34(2): 200–209 (2019-02)

DOI
Sunk Cost Effect in Individuals with Autism Spectrum Disorder.

Junya Fujino, Shisei Tei, Takashi Itahashi, Yuta Aoki, Haruhisa Ohta, Chieko Kanai, Manabu Kubota, Ryu-ichiro Hashimoto, Motoaki Nakamura, Nobumasa Kato, Hidehiko Takahashi

Journal of Autism and Developmental Disorders, 49(1): 1–10 (2019-01)

DOI
Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula

Hitoshi Shinoto, Hitoshi Shimada, Yasumasa Kokubo, Kenji Tagai, Fumitoshi Niwa, Soichiro Kitamura, Hironobu Endo, Maiko Ono, Yasuyuki Kimura, Shigeki Hirano, Maya Mimuro, Masanori Ichise, Naruhiko Sahara, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi

Neurology, 92(2): e136–e147 (2019-01)

DOI
Need for closure and cognitive flexibility in individuals with autism spectrum disorder: A preliminary study.

Junya Fujino, Shisei Tei, Takashi Itahashi, Yuta Aoki, Haruhisa Ohta, Manabu Kubota, Masanori Isobe, Ryu-ichiro Hashimoto, Motoaki Nakamura, Nobumasa Kato, Hidehiko Takahashi

Psychiatry Research, 271: 247–252 (2019-01)

DOI

2018

Comparison of brain activity between motor imagery and mental rotation of the hand tasks: a functional magnetic resonance imaging study

Hiroyuki Hamada, Daisuke Matsuzawa, Chihiro Sutoh, Yoshiyuki Hirano, Sudesna Chakraborty, Hiroshi Ito, Hiroshi Tsuji, Takayuki Obata, Eiji Shimizu

Brain Imaging and Behavior, 12(6): 1596–1606 (2018-12)

DOI
Reward-related brain structures are smaller in patients with schizophrenia and comorbid metabolic syndrome.

J. de Nijs, H. G. Schnack, M. G. J. C. Koevoets, Manabu Kubota, R. S. Kahn, N. E. M. van Haren, W. Cahn

Acta Psychiatrica Scandinavica, 138(6): 581–590 (2018-12)

DOI
Synthesis and characterization of 11C-labeled benzyl amidine derivatives as PET radioligands for GluN2B subunit of the NMDA receptors

Takeshi Fuchigami, Noriko Fujimoto, Terushi Haradahira, Yumiko Nojiri, Takashi Okauchi, Jun Maeda, Tetsuya Suhara, Fumihiko Yamamoto, Morio Nakayama, Minoru Maeda, Takahiro Mukai

Journal of Labelled Compounds and Radiopharmaceuticals, 61(14): 1095–1105 (2018-12)

DOI
Comparison of diffusion-weighted MRI and anti-Stokes Raman scattering (CARS) measurements of the inter-compartmental exchange-time of water in expression-controlled aquaporin-4 cells.

Takayuki Obata, Jeff Kershaw, Yasuhiko Tachibana, Takayuki Miyauchi, Yoichiro Abe, Sayaka Shibata, Hiroshi Kawaguchi, Yoko Ikoma, Hiroyuki Takuwa, Ichio Aoki, Masato Yasui

Scientific reports, 8(1): 17954 (2018-12)

DOI
Hyperpolarized 13C magnetic resonance spectroscopy reveals the rate-limiting role of the blood-brain barrier in the cerebral uptake and metabolism of L-lactate in vivo.

Yuhei Takado, Tian Cheng, Jessica A M Bastiaansen, Hikari A I Yoshihara, Bernard Lanz, Mor Mishkovsky, Sylvain Lengacher, Arnaud Comment

ACS chemical neuroscience, 9(11): 2554–2562 (2018-11)

DOI
Tau-induced focal neurotoxicity and network disruption related to apathy in Alzheimer's disease

Soichiro Kitamura, Hitoshi Shimada, Fumitoshi Niwa, Hironobu Endo, Hitoshi Shinoto, Keisuke Takahata, Manabu Kubota, Yuhei Takado, Shigeki Hirano, Yasuyuki Kimura, Ming-Rong Zhang, Satoshi Kuwabara, Tetsuya Suhara, Makoto Higuchi

Journal of Neurolory, Neurosurgery & Psychiatry, 89(11): 1208–1214 (2018-11)

DOI
Dynamic laminar rerouting of inter-areal mnemonic signal by cognitive operations in primate temporal cortex.

Masaki Takeda, Toshiyuki Hirabayashi, Yusuke Adachi, Yasushi Miyashita

Nature Communications, 9(1): 4629 (2018-11)

DOI
Evaluation of Pancreatic VMAT2 Binding with Active and Inactive Enantiomers of [18F]FP-DTBZ in Healthy Subjects and Patients with Type 1 Diabetes

Mika Naganawa, Keunpoong Lim, Nabeel B. Nabulsi, Shu-fei Lin, David Labaree, Jim Ropchan, Kevan C. Herold, Yiyun Huang, Paul Harris, Masanori Ichise, Gary W. Cline, Richard E. Carson

Molecular Imaging and Biology, 20(5): 835–845 (2018-10)

DOI
Water Diffusion in the Brain of Chronic Hypoperfusion Model Mice: A Study Considering the Effect of Blood Flow.

Takuya Urushihata, Hiroyuki Takuwa, Chie Seki, Yasuhiko Tachibana, Manami Takahashi, Jeff Kershaw, Yuhei Takado, Ichio Aoki, Makoto Higuchi, Hiroshi Ito, Takayuki Obata

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 17(4): 318–324 (2018-10)

DOI
In vivo imaging of Α7 nicotinic receptors as a novel method to monitor neuroinflammation after cerebral ischemia.

Lorena Colas, Maria Domercq, Pedro Ramos-Cabrer, Ana Palma, Vanessa Gomez-Vallejo, Daniel Padro, Sandra Plaza-Garcla, Krishna R. Pulagam, Makoto Higuchi, Carlos Matute, Jordi Llop, Abraham Martin

Glia, 66(8): 1611–1624 (2018-08)

DOI
Dependence of behavioral performance on material category in an object-grasping task with monkeys.

Isao Yokoi, Atsumichi Tachibana, Takafumi Minamimoto, Naokazu Goda, Hidehiko Komatsu

Journal of neurophysiology, 120(2): 553–563 (2018-08)

DOI
Reduced gray matter volume is correlated with frontal cognitive and behavioral impairments in Parkinson's disease

Tatsuhiro Terada, Jun Miyata, Tomokazu Obi, Manabu Kubota, Miho Yoshizumi, Toshiya Murai

Journal of the Neurological Sciences, 390: 231–238 (2018-07)

DOI
Dual tracer tau PET imaging reveals different molecular targets for 11C-THK5351 and 11C-PBB3 in the Alzheimer brain

Konstantinos Chiotis, Per Stenkrona, Ove Almkvist, Vladimir Stepanov, Daniel Ferreira, Ryosuke Arakawa, Akihiro Takano, Eric Westman, Andrea Varrone, Nobuyuki Okamura, Hitoshi Shimada, Makoto Higuchi, Christer Halldin, Agneta Nordberg

European Journal of Nuclear Medicine and Molecular Imaging, 45(9): 1605–1617 (2018-07)

DOI
Amyloid and Tau Positron Emission Tomography in Suggested Diabetesrelated Dementia

Naoto Takenoshita, Raita Fukasawa, Yusuke Ogawa, Soichiro Shimizu, Takahiko Umahara, Kenji Ishii, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Haruo Hanyu

Current Alzheimer Research, 15(11): 1062–1069 (2018-07)

DOI
Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models.

Ruiqing Ni, Bin Ji, Maiko Ono, Naruhiko Sahara, Ming-Rong Zhang, Ichio Aoki, Agneta Nordberg, Tetsuya Suhara, Makoto Higuchi

The Journal of Nuclear Medicine, 59(6): 960–966 (2018-06)

DOI
Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans

Takehito Ito, Yasuyuki Kimura, Chie Seki, Masanori Ichise, Keita Yokokawa, Kazunori Kawamura, Hidehiko Takahashi, Makoto Higuchi, Ming-Rong Zhang, Tetsuya Suhara, Makiko Yamada

European Journal of Nuclear Medicine and Molecular Imaging Research (EJNMMI Research), 8(1): 48 (2018-06)

DOI
Integrated treatment using intraperitoneal radioimmunotherapy and positron emission tomography-guided surgery with 64Cu-labeled cetuximab to treat early- and late-phase peritoneal dissemination in human gastrointestinal cancer xenografts

Yukie Yoshii, Mitsuyoshi Yoshimoto, Hiroki Matsumoto, Hideaki Tashima, Yuma Iwao, Hiroyuki Takuwa, Eiji Yoshida, Hidekatsu Wakizaka, Taiga Yamaya, Ming-Rong Zhang, Aya Sugyo, Sayaka Hanadate, Atsushi Tsuji, Tatsuya Higashi

Oncotarget, 9(48): 28935–28950 (2018-06)

DOI
Microglial Activation During Pathogenesis of Tauopathy in rTg4510 Mice: Implications for the Early Diagnosis of Tauopathy.

Naruhiko Sahara, Jun Maeda, Ai Ishikawa, Masaki Tokunaga, Tetsuya Suhara, Makoto Higuchi

Journal of Alzheimer's Disease, 64(S1): S353–S359 (2018-06)

DOI
Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of Tauopathy

Gen Matsumoto, Kazuki Matsumoto, Taeko Kimura, Tetsuya Suhara, Makoto Higuchi, Naruhiko Sahara, Nozomu Mori

International Journal of Molecular Sciences, 19(5): 1497 (2018-05)

DOI
Inflexible daily behaviour is associated with the ability to control an automatic reaction in autism spectrum disorder.

Shisei Tei, Junya Fujino, Ryu-ichiro Hashimoto, Takashi Itahashi, Haruhisa Ohta, Chieko Kanai, Manabu Kubota, Motoaki Nakamura, Nobumasa Kato, Hidehiko Takahashi

Scientific Reports, 8(1): 8082 (2018-05)

DOI
Neuromolecular basis of faded perception associated with unreality experience.

Keita Yokokawa, Takehito Ito, Keisuke Takahata, Harumasa Takano, Yasuyuki Kimura, Masanori Ichise, Yoko Ikoma, Ayako Isato, Ming-Rong Zhang, Kazunori Kawamura, Hiroshi Ito, Hidehiko Takahashi, Tetsuya Suhara, Makiko Yamada

Scientific Reports, 8(1): 8062 (2018-05)

DOI
Inhibition of Internal Attention to Positive and Negative Representations in Dysphoria1

Ayako Isato, Haruki Nishimura, Makiko Yamada, Satoshi Mochizuki

Japanese Psychological Research, 60(3): 143–155 (2018-04)

DOI
Positron emission tomography of cerebral angiogenesis and TSPO expression in a mouse model of chronic hypoxia.

Iwao Kanno, Chie Seki, Hiroyuki Takuwa, Zhao-Hui Jin, Didier Boturyn, Pascal Dumy, Takako Furukawa, Tsuneo Saga, Hiroshi Ito, Kazuto Masamoto

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 38(4): 687–696 (2018-04)

DOI
Heterogeneous Redistribution of Facial Subcategory Information Within and Outside the Face-Selective Domain in Primate Inferior Temporal Cortex

Naohisa Miyakawa, Kei Majima, Hirohito Sawahata, Keisuke Kawasaki, Takeshi Matsuo, Naoki Kotake, Takafumi Suzuki, Yukiyasu Kamitani, Isao Hasegawa

Cerebral Cortex, 28(4): 1416–1431 (2018-04)

DOI
Sound Frequency Representation in the Auditory Cortex of the Common Marmoset Visualized Using Optical Intrinsic Signal Imaging

Toshiki Tani, Hiroshi Abe, Taku Hayami, Taku Banno, Naohisa Miyakawa, Naohito Kitamura, Hiromi Mashiko, Noritaka Ichinohe, Wataru Suzuki

eNeuro, 5(2) (2018-04)

DOI
Roles of centromedian parafascicular nuclei of thalamus and cholinergic interneurons in the dorsal striatum in associative learning of environmental events

Ko Yamanaka, Yukiko Hori, Takafumi Minamimoto, Hiroshi Yamada, Naoyuki Matsumoto, Kazuki Enomoto, Toshihiko Aosaki, Ann M.Graybiel, Minoru Kimura

Journal of Neural Transmission, 3: 501–513 (2018-03)

DOI
Low signal intensity in motor cortex on susceptibility-weighted MR imaging is correlated with clinical signs of amyotrophic lateral sclerosis: a pilot study

Hironobu Endo, Kenji Sekiguchi, Hitoshi Shimada, Takehiro Ueda, Hisatomo Kowa, Fumio Kanda, Tatsushi Toda

Journal of Neurology, 265(3): 552–561 (2018-03)

DOI
青年におけるBPD症状の重症度を捉えるJapanese version of Quick Evaluation of Severity over Time（QuEST-J）の開発と信頼性・妥当性の検討

伊里綾子, 藤里紘子, 山田圭介, 大久保智紗, 宮前光宏, 寺島瞳

感情心理学研究, 25(1): 1–11 (2018-03)

DOI
In vitro and in vivo evaluation of 11C-labeled azetidine-carboxylates for imaging monoacylglycerol lipase by PET imaging studies

Ran Cheng, Wakana Mori, Longle Ma, Mireille Alhouayek, Akiko Hatori, Yiding Zhang, Daisuke Ogasawara, Gengyang Yuan, Zhen Chen, Xiaofei Zhang, Hang Shi, Tomoteru Yamasaki, Lin Xie, Katsushi Kumata, Masayuki Fujinaga, Yuji Nagai, Takafumi Minamimoto, Mona Svensson, Wang Lu, Yunfei Du, Mary Jo Ondrechen, Neil Vasdev, Benjamin F Cravatt, Christopher Fowler, Ming-Rong Zhang, Steven H Liang

Journal of Medicinal Chemistry, 61: 2278–2291 (2018-02)

DOI
Tau filaments and development of positron emission tomography (PET) tracers

Michel Goedert, Yoshiki Yamaguchi, Sushi K. Mishra, Makoto higuchi, Naruhiko Sahara

Frontiers in Neurology, 9: 70 (2018-02)

DOI
Steroidogenic abnormalities in translocator protein knockout mice and significance in the aging male

Anna Barron, Bin Ji, Seiji Kito, Tetsuya Suhara, Makoto Higuchi

Biochemical Journal, 475(1): 75–85 (2018-01)

DOI
In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510

Ai Ishikawa, Masaki Tokunaga, Jun Maeda, Takeharu Minamihisamatsu, Masafumi Shimojo, Hiroyuki Takuwa, Maiko Ono, Ruiqing Ni, Shigeki Hirano, Satoshi Kuwabara, Bin Ji, Ming-Rong Zhang, Ichio Aoki, Tetsuya Suhara, Makoto Higuchi, Naruhiko Sahara

Journal of Alzheimer's Disease, 61(3): 1037–1052 (2018-01)

DOI
Imaging of neuronal activity in awake mice by measurements of flavoprotein autofluorescence corrected for cerebral blood flow

Takahashi Manami, Takuya Urushihata, Hiroyuki Takuwa, Kazumi Sakata, Yuhei Takado, Eiji Shimizu, Tetsuya Suhara, Makoto Higuchi, Hiroshi Ito

Frontiers Neuroscience, 11(723) (2018-01)

DOI

2017

Occupancy of norepinephrine transporter by duloxetine in human brains measured by positron emission tomography with (S,S)-[18F]FMeNER-D2

Sho Moriguchi, Harumasa Takano, Yasuyuki Kimura, Tomohisa Nagashima, Keisuke Takahata, Manabu Kubota, Soichiro Kitamura, Tatsuya Ishii, Masanori Ichise, Ming-Rong Zhang, Hitoshi Shimada, Masaru Mimura, Jeffrey H. Meyer, Makoto Higuchi, Tetsuya Suhara

The International Journal of Neuropsychopharmacology, 20(12): 957–962 (2017-12)

DOI
Neuroticism associates with cerebral in vivo serotonin transporter binding differently in males and females

Lauri Tuominen, Jouko Miettunen, Dara M Cannon, Wayne C Drevets, Vibe G. Frokjaer, Jussi Hirvonen, Masanori Ichise, Peter S Jensen, Liisa Keltikangas-Jarvinen, Jacqueline M. Klaver, Gitte M. Knudsen, Akihiro Takano, Tetsuya Suhara, Jarmo Hietala

The International Journal of Neuropsychopharmacology, 20(12): 963–970 (2017-12)

DOI
A migration case of Kii amyotrophic lateral sclerosis/parkinsonism dementia complex with the shortest stay in the endemic area and the longest incubation to develop the disease

Keiichiro Tsunoda, Toru Yamashita, Hitoshi Shimada, Emi Nomura, Yoshiaki Takahashi, Jingwei Shang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Makoto Higuchi, Tetsuya Suhara, Yasumasa Kokubo, Shigeki Kuzuhara, Koji Abe

Journal of Clinical Neuroscience (2017-12)

DOI
Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain

Tatsuya Ishii, Yasuyuki Kimura, Masanori Ichise, Keisuke Takahata, Soichiro Kitamura, Sho Moriguchi, Manabu Kubota, Ming-Rong Zhang, Makiko Yamada, Makoto Higuchi, Yoshinori Okubo, Tetsuya Suhara

PLOS ONE, 12(12): e0189318 (2017-12)

DOI
In vivo tau imaging for a diagnostic platform of tauopathy using the rTg4510 mouse line

Naruhiko Sahara, Masafumi Shimojo, Maiko Ono, Hiroyuki Takuwa, Febo Marcelo, Makoto Higuchi, Tetsuya Suhara

Frontiers in Neurology, 8(663) (2017-12)

DOI
Affinity states of striatal dopamine D2 receptors in antipsychotic-free patients with schizophrenia

Manabu Kubota, Tomohisa Nagashima, Harumasa Takano, Fumitoshi Kodaka, Hironobu Fujiwara, Keisuke Takahata, Sho Moriguchi, Yasuyuki Kimura, Makoto Higuchi, Yoshiro Okubo, Hidehiko Takahashi, Hiroshi Ito, Tetsuya Suhara

The International Journal of Neuropsychopharmacology, 20(11): 928–935 (2017-11)

DOI
Novel method of extracting motion from natural movies

Wataru Suzuki, Noritaka Ichinohe, Toshiki Tani, Taku Hayami, Naohisa Miyakawa, Satoshi Watanabe, Hiroshige Takeichi

Journal of neuroscience methods, 291: 51–60 (2017-11)

DOI
Localized accumulation of tau without amyloid-beta in aged brains measured with [11C]PBB3 and [11C]PiB positron emission tomography

Takayuki Kikukawa, Haruna Saito, Itsuki Hasegawa, Jun Takeuchi, Akitoshi Takeda, Joji Kawabe, Yasuhiro Wada, Aya Mawatari, Yasuyoshi Watanabe, Soichiro Kitamura, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Yoshiaki Itoh

Journal of Alzheimer's Disease & Parkinsonism, 7(6) (2017-11)

DOI
High-contrast PET imaging of vasopressin V1B receptors with a novel radioligand, 11C-TASP699

Kazumi Koga, Yuji Nagai, Masayuki Hanyu, Mitsukane Yoshinaga, Shigeyuki Chaki, Norikazu Ohtake, Satoshi Ozaki, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi

Journal of nuclear medicine, 58(10): 1652–1658 (2017-10)

DOI
Comparison between [18F]fluorination and [18F]fluoroethylation reactions for the synthesis of the PDE10A PET radiotracer [18F]MNI-659

Wakana Mori, Makoto Takei, Kenji Furutsuka, Masayuki Fujinaga, Katsushi Kumata, Masatoshi Muto, Takayuki Ohkubo, Hiroki Hashimoto, Gilles Tamagnan, Makoto Higuchi, Kazunori Kawamura, Ming-Rong Zhang

Nuclear Medicine and Biology, 55: 12–18 (2017-10)

DOI
Possible role of organic cation transporters in the distribution of [11C]sulpiride, a dopamine D2 receptor antagonist

Harumasa Takano, Sumito Ito, Xuan Zhang, Hiroshi Ito, Ming-Rong Zhang, Hiroshi Suzuki, Kazuya Maeda, Hiroyuki Kusuhara, Tetsuya Suhara, Yuichi Sugiyama

Journal of Pharmaceutical Sciences, 106(9): 2558–2565 (2017-09)

DOI
Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine transporters, and dopamine D2 receptors

Hiroshi Ito, Hiroshi Kawaguchi, Fumitoshi Kodaka, Hiroyuki Takuwa, Yoko Ikoma, Hitoshi Shimada, Yasuyuki Kimura, Chie Seki, Hitoshi Kubo, Shiro Ishii, Harumasa Takano, Tetsuya Suhara

NeuroImage, 158: 12–17 (2017-09)

DOI
Biomathematical screening of amyloid radiotracers with clinical usefulness index

Ying-Hwey Nai, Miho Shidahara, Chie Seki, Hiroshi Watabe

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 3(4): 542–552 (2017-09)

DOI
Prediction of the clinical standardized uptake value ratio in amyloid PET imaging using a biomathematical modeling approach towards the efficient development of a radioligand.

Yuma Arakawa, YingHwey Nai, Miho Shidahara, Shozo Furumoto, Chie Seki, Nobuyuki Okamura, Manabu Tashiro, Yukitsuka Kudo, Kazuhiko Yanai, Kohsuke Gonda, Hiroshi Watabe

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 58(8): 1285–1292 (2017-08)

DOI
Distinct Functions of the Primate Putamen Direct and Indirect Pathways in Adaptive Outcome-Based Action Selection

Yasumasa Ueda, Ko Yamanaka, Atsushi Noritake, Kazuki Enomoto, Naoyuki Matsumoto, Hiroshi Yamada, Kazuyuki Samejima, Hitoshi Inokawa, Yukiko Hori, Kae Nakamura, Minoru Kimura

Frontiers in neuroanatomy (2017-08)

DOI
A human PET study of [¹¹C]HMS011, a potential radioligand for AMPA receptors

Keisuke Takahata, Yasuyuki Kimura, Chie Seki, Masaki Tokunaga, Masanori Ichise, Kazunori Kawamura, Maiko Ono, Soichiro Kitamura, Manabu Kubota, Sho Moriguchi, Tatsuya Ishii, Yuhei Takado, Fumitoshi Niwa, Hironobu Endo, Tomohisa Nagashima, Yoko Ikoma, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi

EJNMMI Research, 7(63) (2017-08)

DOI
Attitudes toward risk and ambiguity in patients with autism spectrum disorder

Junya Fujino, Shisei Tei, Ryu-ichiro Hashimoto, Takashi Itahashi, Haruhisa Ohta, Chieko Kanai, Rieko Okada, Manabu Kubota, Motoaki Nakamura, Nobumasa Kato, Hidehiko Takahashi

Molecular Autism (2017-08)

DOI
Conversion of object identity to object-general semantic value in the primate temporal cortex

Keita Tamura, Masaki Takeda, Rieko Setsuie, Tadashi Tsubota, Toshiyuki Hirabayashi, Kentaro Miyamoto, Yasushi Miyashita

Science, 357(6352): 687–692 (2017-08)

DOI
Altered awareness of action in Parkinson's disease: evaluations by explicit and implicit measures

Naho Saito, Keisuke Takahata, Hodaka Yamakado, Nobukatsu Sawamoto, Satoshi Saito, Ryosuke Takahashi, Toshiya Murai, Hidehiko Takahashi

SCIENTIFIC REPORTS, 7(1): 8019 (2017-08)
PET quantification of the norepinephrine transporter in human brain with (S,S)-18F-FMeNER-D2.

Sho Moriguchi, Yasuyuki Kimura, Masanori Ichise, Ryosuke Arakawa, Harumasa Takano, Chie Seki, Yoko Ikoma, Keisuke Takahata, Tomohisa Nagashima, Makiko Yamada, Masaru Mimura, Tetsuya Suhara

Journal of nuclear medicine : official publication, Society of Nuclear Medicine (2017-07)

DOI
Distinct Patterns of Cerebral Cortical Thinning in Schizophrenia: A Neuroimaging Data-Driven Approach.

Genichi Sugihara, Naoya Oishi, Shuraku Son, Manabu Kubota, Hidehiko Takahashi, Toshiya Murai

Schizophrenia bulletin, 43(4): 900–909 (2017-07)

DOI
Use of human methylation arrays for epigenome research in the common marmoset (Callithrix jacchus)

Junko Ueda, Yui Murata, Miki Bundo, Arata Oh-Nishi, Hidetoshi Kasai, Tempei Ikegame, Zhilei Zhao, Seiichiro Jinde, Atsu Aiba, Tetsuya Suhara, Kiyoko Kasai, Tadafumi Kato, Kazuya Iwamoto

Neuroscience Research, 120: 60–65 (2017-07)

DOI
PBB3 Imaging in Parkinsonian disorders: evidence for binding to Tau and other proteins

Alexandra Perez-Soriano, Julieta E. Arena, Katie Dinelle, Qing Miao, Jessamyn McKenzie, Nicole Neilson, Andreas Puschmann, Paul Schaffer, Hitoshi Shinoto, Jenna Smith-Forrester, Elham Shahinfard, Nasim Vafai, Daryl wile, Zbigniew Wszolek, Makoto Higuchi, Vesna Sossi, A. Jon Stoessl

Movement Disorders, 32(7): 1016–1024 (2017-07)

DOI
3D reconstruction of brain section images for creating axonal projection maps in marmosets

Hiroshi Abe, Toshiki Tani, Hiromi Mashiko, Naohito Kitamura, Naohisa Miyakawa, Koki Mimura, Kazuhisa Sakai, Wataru Suzuki, Tohru Kurotani, Hiroaki Mizukami, Akiya Watakabe, Tetsuo Yamamori, Noritaka Ichinohe

Journal of neuroscience methods, 286(286): 102–113 (2017-07)

DOI
Resting-State Functional Connectivity-Based Biomarkers and Functional MRI-Based Neurofeedback for Psychiatric Disorders: A Challenge for Developing Theranostic Biomarkers.

Takashi Yamada, Ryu-ichiro Hashimoto, Noriaki Yahata, Naho Ichikawa, Yujiro Yoshihara, Yasumasa Okamoto, Nobumasa Kato, Hidehiko Takahashi, Mitsuo Kawato

International Journal of Neuropsychopharmacology, 20(10): 769–781 (2017-07)

DOI
Fluorescence and Autoradiographic Evaluation of Tau PET Ligand PBB3 to α-Synuclein Pathology

Shunsuke Koga, Maiko Ono, Naruhiko Sahara, Makoto Higuchi, Dennis W. Dickson

Movement Disorders, 32(6): 884–892 (2017-06)

DOI
Erratum to "Impact of spillover from white matter by partial volume effect on quantification of amyloid deposition with [11C]PiB PET" [NeuroImage 143 (2016) 316-324].

Keisuke Matsubara, Masanobu Ibaraki, Hitoshi Shimada, Yoko Ikoma, Tetsuya Suhara, Toshibumi Kinoshita, Hiroshi Ito

NeuroImage, 143: 411 (2017-06)

DOI
Visual evaluation of kinetic characteristics of PET probe for neuroreceptors using a two-phase graphic plot analysis

Hiroshi Ito, Yoko Ikoma, Chie Seki, Yasuyuki Kimura, Hiroshi Kawaguchi, Hiroyuki Takuwa, Masanori Ichise, Tetsuya Suhara, Iwao Kanno

Annals of Nuclear Medicine, 31(4): 273–282 (2017-05)

DOI
Glucose uptake of the muscle and adipose tissues in diabetes and obesity disease models: evaluation of insulin and β3-adrenergic receptor agonist effects by 18F-FDG

Seigo Ishino, Taku Sugita, Yusuke Kondo, Mika Okai, Kazue Tsuchimori, Masanori Watanabe, Ikuo Mori, Masaki Hosoya, Takashi Horiguchi, Hidenori Kamiguchi

Annal Nuc Med, 31(5): 413–423 (2017-05)

DOI
Strategies for utilizing neuroimaging biomarkers in CNS drug discovery and development: CINP/JSNP working group report.

Tetsuya Suhara, Shigeyuki Chaki, Haruhide Kimura, Makoto Furusawa, Mitsuyuki Matsumoto, Hiroo Ogura, Takaaki Negishi, Takeaki Saijo, Makoto Higuchi, Tomohiro Omura, Rira Watanabe, Sosuke Miyoshi, Noriaki Nakatani, Noboru Yamamoto, Shyh-Yuh Liou, Yuhei Takado, Jun Maeda, Yasumasa Okamoto, Yoshiaki Okubo, Makiko Yamada, Hiroshi Ito, Noah M Walton, Shigeto Yamawaki

The international journal of neuropsychopharmacology, 20(4): 285–294 (2017-04)

DOI
Deficit of state-dependent risk attitude modulation in gambling disorder

Atsushi Fujimoto, Kosuke Tsurumi, Ryosaku Kawada, Takuro Murao, Hideaki Takeuchi, Toshiya Murai, Hidehiko Takahashi

Translational Psychiatry, 7(4): e1085 (2017-04)

DOI
Frontal assessment battery and frontal atrophy in amyotrophic lateral sclerosis

Tatsuhiro Terada, Jun Miyata, Tomokazu Obi, Manabu Kubota, Miho Yoshizumi, Kinya Yamazaki, Kouichi Mizoguchi, Toshiya Murai

Brain and Behavior, 7(6): e00707 (2017-04)

DOI
Changes in effective diffusivity for oxygen during neural activation and deactivation estimated from capillary diameter measured by two-photon laser microscope.

Hiroshi Ito, Hiroyuki Takuwa, Yosuke Tajima, Hiroshi Kawaguchi, Takuya Urushihata, Junko Taniguchi, Yoko Ikoma, Chie Seki, Masanobu Ibaraki, Kazuto Masamoto, Iwao Kanno

The journal of physiological sciences : JPS, 67(2): 325–330 (2017-03)

DOI
Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies.

Maiko Ono, Naruhiko Sahara, Katsushi Kumata, Bin Ji, Ruiqing Ni, Shunsuke Koga, Dennis W Dickson, John Q Trojanowski, Virginia M-Y Lee, Mari Yoshida, Isao Hozumi, Yasumasa Yoshiyama, John C van Swieten, Agneta Nordberg, Tetsuya Suhara, Ming-Rong Zhang, Makoto Higuchi

Brain : a journal of neurology, 140(3): 764–780 (2017-03)

DOI
Sleep Apnea in Multiple System Atrophy of Cerebellar Type: A 3.0 T MRS/Volumetry Pilot Study

Yuhei Takado, Kenshi Terajima, Takayoshi Shimohata, Hideaki Nakayama, Masaki Watanabe, Kouichirou Okamoto, Tetsutaro Ozawa, Masatoyo Nishizawa, Ingrid L. Kwee, Hironaka Igarashi, Tsutomu Nakada

eNeurologicalSci, 6: 6–8 (2017-03)

DOI
Neural basis of negativity bias in the perception of ambiguous facial expression

Takehito Ito, Keita Yokokawa, Noriaki Yahata, Ayako Isato, Tetsuya Suhara, Makiko Yamada

Scientific Reports, 7(1): 420-1–420-9 (2017-03)

DOI
Measurement of psychological state changes at low dopamine transporter occupancy following a clinical dose of mazindol

Yasuyuki Kimura, Jun Maeda, Makiko Yamada, Keisuke Takahata, Keita Yokokawa, Yoko Ikoma, Chie Seki, Hiroshi Ito, Makoto Higuchi, Tetsuya Suhara

Psychopharmacology, 234(3): 323–328 (2017-02)

DOI
Propagation of pathological α-synuclein in marmoset brain

Aki Shimozawa, Maiko Ono, Daisuke Takahara, Airi Tarutani, Sei Imura, Masami Masuda-Suzukake, Makoto Higuchi, Kazuhiko Yanai, Shin-ichi Hisanaga, Masato Hasegawa

Acta Neuropathologica Communications, 5: 12-1–12-14 (2017-02)

DOI
Norepinephrine Transporter in Major Depressive Disorder: A PET Study.

Sho Moriguchi, Makiko Yamada, Harumasa Takano, Tomohisa Nagashima, Keisuke Takahata, Keita Yokokawa, Takehito Ito, Tatsuya Ishii, Yasuyuki Kimura, Ming-Rong Zhang, Masaru Mimura, Tetsuya Suhara

The American journal of psychiatry, 174(1): 36–41 (2017-01)

DOI
Altered tau isoform ratio caused by loss of FUS and SFPQ function leads to FTLD-like phenotypes

Shinsuke Ishigaki, Yusuke Fujioka, Yohei Okada, Yuichi Riku, Tsuyoshi Udagawa, Daiyu Honda, Satoshi Yokoi, Kuniyuki Endo, Kensuke Ikenaka, Shinnosuke Takagi, Yohei Iguchi, Naruhiko Sahara, Akihiko Takashima, Hideyuki Okano, Mari Yoshida, Hitoshi Warita, Masashi Aoki, Hirohisa Watanabe, Haruo Okado, Masahisa Katsuno, Gen Sobue

Cell reports, 18(5): 1118–1131 (2017-01)

DOI
Association between Aβ and tau accumulations and their influence on clinical features in aging and Alzheimer’s disease spectrum brains: A [11C]PBB3-PET study

Hitoshi Shimada, Soichiro Kitamura, Hitoshi Shinoto, Hironobu Endo, Fumitoshi Niwa, Shigeki Hirano, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi, Yasuyuki Kimura, Satoshi Kuwabara

Alzheimers Dement (Amst), 6: 11–20 (2017-01)

DOI

2016

A possible serologic biomarker for maternal immune activation-associated neurodevelopmental disorders found in the rat models.

Arata Oh-Nishi, Kaori Koga, Tadakazu Maeda, Tetsuya Suhara

Neuroscience research, 113: 63–70 (2016-12)

DOI
Prediction of CNS occupancy of dopamine D2 receptor based on systemic exposure and in vitro experiments

Kayoko Kanamitsu, Ryosuke Arakawa, Yuichi Sugiyama, Tetsuya Suhara, Hiroyuki Kusuhara

Drug Metabolism and Pharmacokinetics, 31(6): 395–404 (2016-12)

DOI
Impact of spillover from white matter by partial volume effect on quantification of amyloid deposition with [(11)C]PiB PET.

Keisuke Matsubara, Masanobu Ibaraki, Hitoshi Shimada, Yoko Ikoma, Tetsuya Suhara, Toshibumi Kinoshita, Hiroshi Ito

NeuroImage, 143: 316–324 (2016-12)

DOI
PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation.

Yuji Nagai, Erika Kikuchi, Walter Lerchner, Ken-ichi Inoue, Bin Ji, Mark A.G. Eldridge, Hiroyuki Kaneko, Yasuyuki Kimura, Arata Oh-Nishi, Yukiko Hori, Yoko Kato, Toshiyuki Hirabayashi, Atsushi Fujimoto, Katsushi Kumata, Ming-Rong Zhang, Ichio Aoki, Tetsuya Suhara, Makoto Higuchi, Masahiko Takada, Barry J. Richmond, Takafumi Minamimoto

Nature Communications, 7: 13605-1–13605-8 (2016-12)

DOI
Compensation, insurance, and management of injuries in investigator-initiated clinical trials in Japan

Chieko Kurihara, Junko Hoshi, Chieko Suzuki, Kazuko Suzuki, Hiroi Kasai, Noriko Morishita, Yayoi Sato, Tetsuya Suhara, Hiroshi Watanabe

Japanese Journal of Clinical Pharmacology, 47(6): 219–228 (2016-12)

DOI
情動的情報が記銘に与える影響と抑うつ傾向の関連

伊里綾子, 望月聡

感情心理学研究（Japanese Journal of Research on Emotions）, 23(3): 105–115 (2016-12)

DOI
Multimodal Imaging for DREADD-expressing Neurons in Living Brain and Their Application to Implantation of iPSC-derived Neural Progenitors

BIN JI, Hiroyuki Kaneko, Takafumi Minamimoto, Haruhisa Inoue, Hiroki Takeuchi, Katsushi Kumata, Ming-Rong Zhang, Ichio Aoki, Chie Seki, Maiko Ono, Masaki Tokunaga, Satoshi Tsukamoto, Koji Tanabe, Ryong-Moon Shin, Takeharu Minamihisamatsu, Seiji Kito, Barry J. Richmond, Tetsuya Suhara, Makoto Higuchi

The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(45): 11544–11558 (2016-11)

DOI
Flexible Modulation of Risk Attitude during Decision-Making under Quota

Atsushi Fujimoto, Hidehiko Takahashi

NeuroImage, 139: 304–312 (2016-10)

DOI
Inhibitory effects of caffeine on gustatory plasticity in the nematode Caenorhabditis elegans.

Takuya Urushihata, Hiroyuki Takuwa, Yukako Higuchi, Kazumi Sakata, Tokumitsu Wakabayashi, Asuka Nishino, Tetsuya Matsuura

Bioscience, biotechnology, and biochemistry, 80(10): 1990–1994 (2016-10)

DOI
Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons.

Keiko Imamura, Naruhiko Sahara, Nicholas M Kanaan, Kayoko Tsukita, Takayuki Kondo, Yumiko Kutoku, Yutaka Ohsawa, Yoshihide Sunada, Koichi Kawakami, Akitsu Hotta, Satoshi Yawata, Dai Watanabe, Masato Hasegawa, John Q Trojanowski, Virginia M-Y Lee, Tetsuya Suhara, Makoto Higuchi, Haruhisa Inoue

Scientific reports, 6: 34904-1–34904-10 (2016-10)

DOI
Laminar module cascade from layer 5 to 6 implementing cue-to-target conversion for object memory retrieval in the primate temporal cortex

Kenji W Koyano, Masaki Takeda, Teppei Matsui, Toshiyuki Hirabayashi, Yohei Ohashi, Yasushi Miyashita

Neuron, 92(2): 518–529 (2016-10)

DOI
Development of a Simultaneous Optical / PET Imaging System for Awake

Hiroyuki Takuwa, Yoko Ikoma, Eiji Yoshida, Hideaki Tashima, Hidekatsu Wakizaka, Tetsuya Shinaji, Taiga Yamaya

Physics in Medicine and Biology, 61(17): 6430–6440 (2016-09)

DOI
Dynamic flow velocity mapping from fluorescent dye transit times in the brain surface microcirculation of anesthetized rats and mice.

Ryo Hoshikawa, Hiroshi Kawaguchi, Hiroyuki Takuwa, Yoko Ikoma, Yutaka Tomita, Miyuki Unekawa, Norihiro Suzuki, Iwao Kanno, Kazuto Masamoto

Microcirculation (New York, N.Y. : 1994), 23(6): 416–425 (2016-08)

DOI
Food Search Strategy Changes in Caenorhabditis elegans under Chronic Starvation Conditions.

Takuya Urushihata, Hiroyuki Takuwa, Asuka Nishino, Aki Kikuchi, Akiyoshi Ichijo, Chie Obara, Tokumitsu Wakabayashi, Kazumi Sakata, Tetsuya Matsuura

Journal of experimental zoology. Part A, Ecological genetics and physiology, 325(7): 409–414 (2016-08)

DOI
Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET.

Anna Barron, Masaki Tokunaga, Ming-Rong Zhang, Bin Ji, Tetsuya Suhara, Makoto Higuchi

Journal of neuroinflammation, 13(1): 221-1–221-14 (2016-08)

DOI
Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized (13) C-Labeled Molecular Probe.

Tatsuya Nishihara, Hikari A I Yoshihara, Hiroshi Nonaka, Yoichi Takakusagi, Fuminori Hyodo, Kazuhiro Ichikawa, Emine Can, Jessica A M Bastiaansen, Yuhei Takado, Arnaud Comment, Shinsuke Sando

Angewandte Chemie (International ed. in English), 55(36): 10626–10629 (2016-08)

DOI
Radiosynthesis and in vivo Evaluation of Carbon-11 (2S)-3-(1H-Indol-3-yl)-2-{[(4-methoxyphenyl)carbamoyl]amino}-N-{[1-(5-methoxypyridin-2-yl)cyclohexyl]methyl}propanamide: An Attempt to Visualize Brain Formyl Peptide Receptors in Mouse Models of Neuroinflammation.

Enza Lacivita, Madia Letizia Stama, Jun Maeda, Masayuki Fujinaga, Akiko Hatori, Ming-Rong Zhang, Nicola A Colabufo, Roberto Perrone, Makoto Higuchi, Tetsuya Suhara, Marcello Leopoldo

Chemistry & biodiversity, 13(7): 875–883 (2016-07)

DOI
TASP0434299: A novel pyridopyrimidin-4-one derivative as a radioligand for vasopressin V1B receptor

Kazumi Koga, Mitsukane Yoshinaga, Yoshikatsu Uematsu, Yuji Nagai, Naoki Miyakoshi, Yoko Shimoda, Masayuki Fujinaga, Takafumi Minamimoto, Ming-Rong Zhang, Makoto Higuchi, Norikazu Ohtake, Tetsuya Suhara, Shigeyuki Chaki

Journal of Pharmacology and Experimental Therapeutics, 357(3): 495–508 (2016-06)

DOI
Synthesis and Preclinical Evaluation of Sulfonamido-based [11C-Carbonyl]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase

Lu Wang, Wakana Mori, Ran Cheng, Joji Yui, Akiko Hatori, Longle Ma, Yiding Zhang, Benjamin H. Rotstein, Masayuki Fujinaga, Yoko Shimoda, Tomoteru Yamasaki, Lin Xie, Yuji Nagai, Takafumi Minamimoto, Makoto Higuchi, Neil Vasdev, Ming-Rong Zhang, Steven H. Liang

Theranostics, 6(8): 1145–1159 (2016-05)

DOI
In vivo imaging of neuroinflammation in Alzheimer’s disease

Makoto Higuchi, Bin Ji, Jun Maeda, Naruhiko Sahara, Tetsuya Suhara

Clinical and Experimental Neuroimmunology, 7(2): 139–144 (2016-05)

DOI
Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats.

Venkatesh Gopalan, Navin Michael, Seigo Ishino, Swee Shean Lee, Adonsia Yating Yang, K N Bhanu Prakash, Jadegoud Yaligar, Suresh Anand Sadananthan, Manami Kaneko, Zhihong Zhou, Yoshinori Satomi, Megumi Hirayama, Hidenori Kamiguchi, Bin Zhu, Takashi Horiguchi, Tomoyuki Nishimoto, S Sendhil Velan

Scientific reports, 6: 26445-1–26445-10 (2016-05)

DOI
Long-term effects of cerebral hypoperfusion on neural density and function using misery perfusion animal model.

Asuka Nishino, Yosuke Tajima, Hiroyuki Takuwa, Kazuto Masamoto, Junko Taniguchi, Hidekatsu Wakizaka, Daisuke Kokuryo, Takuya Urushihata, Ichio Aoki, Iwao Kanno, Yutaka Tomita, Norihiro Suzuki, Yoko Ikoma, Hiroshi Ito

Scientific Reports, 6: 25072-1–25072-8 (2016-04)

DOI
Crossmodal Association of Visual and Haptic Material Properties of Objects in the Monkey Ventral Visual Cortex.

Naokazu Goda, Isao Yokoi, Atsumichi Tachibana, Takafumi Minamimoto, Hidehiko Komatsu

Current biology : CB, 26(7): 928–934 (2016-04)

DOI
Characteristics of fast-spiking neurons in the striatum of behaving monkeys.

Hiroshi Yamada, Hitoshi Inokawa, Yukiko Hori, Xiaochuan Pan, Ryuichi Matsuzaki, Kae Nakamura, Kazuyuki Samejima, Munetaka Shidara, Minoru Kimura, Masamichi Sakagami, Takafumi Minamimoto

Neuroscience research, 105: 2–18 (2016-04)

DOI
Principal Component Analysis of Multimodal Neuromelanin MRI and Dopamine Transporter PET Data Provides a Specific Metric for the Nigral Dopaminergic Neuronal Density.

Hiroshi Kawaguchi, Hitoshi Shimada, Fumitoshi Kodaka, Masayuki Suzuki, Hitoshi Shinotoh, Shigeki Hirano, Jeff Kershaw, Yuichi Inoue, Masaki Nakamura, Taeko Sasai, Mina Kobayashi, Tetsuya Suhara, Hiroshi Ito

PloS one, 11(3): e0151191-1–e0151191-13 (2016-03)

DOI