Sector for Connectomic And Translational Dementia research (Sector for CAT Dr.)
We study pathological circuit mechanisms of dementia based on a novel approach of tau-network mapping in human patients combined with genetic neuromodulation in non-human primates to establish a novel target for neuromodulation to improve symptoms. We also study more basic neuroscience with non-human primates for causal elucidation of multi-scale network operations for cognition and affection by combining genetic neuromodulation, functional neuroimaging, and electrophysiology.
Director:
Toshiyuki Hirabayashi, Ph.D.
Toshiyuki Hirabayashi studies 1. tau-network mapping in human patients with tau-PET and rs-fMRI 2. multi-scale causal network analysis for cognitive memory and affection by combining chemogenetics, functional imaging, and electrophysiology in non-human primates 3. local circuit operations with multiple single-unit recordings in non-human primates. He loves his wife, two children, and all the cats in the world.
Members
Toshiyuki Hirabayashi, Principal Researcher
Keisuke Takahata, Senior Researcher
Hironobu Endo, Senior Researcher
Yuki Hori, Researcher
Kenji Tagai, Researcher
Yuki Momota, Postdoctoral Researcher
Shin Kurose, Research Associate
Selected Publications：
Miyakawa, N., Nagai, Y., Hori, Y., Mimura, K., Orihara, A., Oyama, K., Matsuo, T., Inoue, K., Suzuki, T., Hirabayashi, T., Suhara, T., Takada, M., Higuchi, M., Kawasaki, K., Minamimoto, T. Chemogenetic attenuation of cortical seizures in nonhuman primates. Nature Commun. (2023) 14, 971.
Hori, Y., Nagai, Y., Hori, Y., Oyama, K., Mimura, K., Hirabayashi, T., Inoue, K., Fujinaga, M., Zhang, M-R., Takada, M., Higuchi, M., Minamimoto, T. Multimodal Imaging for Validation and Optimization of Ion Channel-Based Chemogenetics in Nonhuman Primates. J. Neurosci. (2023) 43, 6619-6627.
Endo, H., Tagai, K., Ono, M., Ikoma, Y., Oyama, A., Matsuoka, K., Kokubo, N., Hirata, K., Sano, Y., Oya, M., Matsumoto, H., Kurose, S., Seki C, Shimizu H, Kakita A, Takahata, K., Shinoto, H., Shimada, H., Tokuda, T., Kawamura, K., Zhang, MR, Oishi, K., Mori, S., Takado, Y., Higuchi, M. A Machine Learning–Based Approach to Discrimination of Tauopathies Using [18F]PM-PBB3 PET Images. Mov Disord., 2022, 37, 2236-2246.
Momota, Y., Konishi, M., Takahata, K., Kishimoto, T., Tezuka, T., Bun, S., Tabuchi, H., Ito, D., Mimura, M. Case report: Non-Alzheimer's disease tauopathy with logopenic variant primary progressive aphasia diagnosed using amyloid and tau PET. Front Neurol. (2022) 13, 1049113.
*Hirabayashi, T., Nagai, Y., Hori, Y., Inoue, K., Aoki, I., Takada, M., Suhara, T., Higuchi, M., Minamimoto, T. Chemogenetic sensory fMRI reveals behaviorally relevant bidirectional changes in primate somatosensory network. Neuron (2021) 109, 3312-3322. (*: corresponding author)
Tagai, K., Ono, M., Kubota, M., Kitamura, S., Takahata, K., Seki, C., Takado, Y., Shinotoh, H., Sano, Y., Yamamoto, Y., Matsuoka, K., Takuwa, H., Shimojo, M., Takahashi, M., Kawamura, K., Kikuchi, T., Okada, M., Akiyama, H., Suzuki, H., Onaya, M., Takeda , T., Arai, K., Arai, N., Araki, N., Saito, Y., Trojanowski, JQ., Lee, VMY., Mishra, SK., Yamaguchi, Y., Kimura, Y., Ichise, M., Tomita, Y., Zhang, M-R., Suhara, T., Shigeta, M., Sahara, N., Higuchi, M., Shimada, H. High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies. Neuron (2021) 109, 42-58.
Oyama, K., Hori, Y., Nagai, Y., Miyakawa, N., Mimura, K., Hirabayashi, T., Inoue, K., Suhara, T., Takada, M., Higuchi, M., Minamimoto, T. Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making. Science Adv. (2021) 7, eabg4246.
Kurose, S., Kubota,M., Takahata, K., Yamamoto, Y., Fujiwara, H., Kimura, Y., Ito, H., Takeuchi, H., Mimura, M., Suhara, T., Higuchi, M. Relationship between regional gray matter volumes and dopamine D2 receptor and transporter in living human brains. (2021) Hum Brain Mapp. 42, 4048-4058.
Nagai, Y., Miyakawa, N., Takuwa, H., Hori, Y., Oyama, K., Ji, B., Takahashi, M., Huang, XP., Slocum, ST., DiBerto, JF., Xiong, Y., Urushihata, T., Hirabayashi, T., Fujimoto, A., Mimura, K., English, JG., Liu, J., Inoue, K., Kumata, K., Seki, C., Ono, M., Shimojo, M., Zhang, MR., Tomita, Y., Nakahara, J., Suhara, T., Takada, M., Higuchi, M., Jin, J., Roth, BL., Minamimoto, T. Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys. Nature Neurosci. (2020) 23, 1157-1167.
Takahata, K., Kimura, Y., Sahara, N., Koga, S., Shimada, H., Ichise, M., Saito, F., Moriguchi, S., Kitamura, S., Kubota, M., Umeda, S., Niwa, F., Mizushima, J., Yoko Morimoto, Y., Funayama, M., Tabuchi, H., Bieniek, KF., Kawamura, K., Zhang, M-R., Dickson, DW., Mimura, M., Kato, M., Suhara, T., Higuchi, M. PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury. Brain (2019) 142, 3265-3279.
Takeda, M., Hirabayashi, T., Adachi, Y., Miyashita, Y. Dynamic laminar rerouting of inter-areal mnemonic signal by cognitive operations in primate temporal cortex. Nature Commun. (2018) 9, 4629.
Tamura, K., Takeda, M., Setsuie, R., Tsubota, T., Hirabayashi, T., Miyamoto, K., Miyashita, Y. Conversion of object identity to object-general semantic value in the primate temporal cortex. Science. (2017) 357, 687-692.
Koyano, K.W., Takeda M., Matsui, T., Hirabayashi, T., Ohashi, Y., Miyashita, Y. Laminar module cascade from layer 5 to 6 implementing cue-to-target conversion for object memory retrieval in the primate temporal cortex. Neuron. (2016) 92, 518-529.
Nagai, Y., Kikuchi, E., Lerchner, W., Inoue, K., Ji, B., Eldridge, MAG. Kaneko, H., Kimura, Y., Oh-Nishi, A., Hori, Y., Kato, Y., Hirabayashi, T., Fujimoto, A., Kumata, K., Ming-Rong Zhang, M-R., Aoki, I., Suhara, T., Higuchi M., Takada, M., Richmond, BJ., Minamimoto, T. PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation. Nature Commun. (2016) 7, 13605.
*Hirabayashi, T., Tamura, K., Takeuchi, D., Takeda, M., Koyano, K.W., Miyashita, Y. Distinct neuronal interactions in anterior inferotemporal areas of macaque monkeys during retrieval of object association memory. J. Neurosci. (2014) 34, 9377-9388. (*: corresponding author)
Hirabayashi, T., Miyashita, Y. Computational principles of microcircuits for visual object processing in the macaque temporal cortex. Trends Neurosci. (2014) 37, 178-187.
Hirabayashi, T., Takeuchi, D., Tamura, K., Miyashita, Y. Microcircuits for hierarchical elaboration of object coding across primate temporal areas. Science. (2013) 341, 191-195.
Hirabayashi, T., Takeuchi, D., Tamura, K., Miyashita, Y. Functional micro-circuit recruited during retrieval of object association memory in monkey perirhinal cortex. Neuron. (2013) 77, 192-203.
#Miyamoto, K., #Hirabayashi, T., Miyashita, Y. To bet, or not to bet: that is the question of SEF spikes. Neuron. (2012) 75, 358-360. (#: These authors equally contributed.)
Takeuchi, D., Hirabayashi, T., Tamura, K., Miyashita, Y. Reversal of interlaminar signal between sensory and memory processing in monkey temporal cortex. Science. (2011) 331, 1443-1447.
Hirabayashi, T., Takeuchi, D., Tamura, K., Miyashita, Y. Triphasic dynamics of stimulus-dependent information flow between single neurons in macaque inferior temporal cortex. J. Neurosci. (2010) 30, 10407-10421.
Hirabayashi, T., Miyashita, Y. Dynamically modulated spike correlation in monkey inferior temporal cortex depending on the feature configuration within a whole object. J. Neurosci. (2005) 25, 10299-10307.
